Results 61 to 70 of about 3,012,345 (281)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

An innovative natural speed breeding technique for accelerated chickpea (Cicer arietinum L.) generation turnover

Plant Methods
Background The slow breeding cycle presents a significant challenge in legume research and breeding. While current speed breeding (SB) methods promise faster plant turnover, they encounter space limitations and high costs. Enclosed environments risk pest
S. Gurumurthy, Apoorva Ashu, S. Kruthika, Amol P. Solanke, T. Basavaraja, Khela Ram Soren, Jagadish Rane, Himanshu Pathak, P. V. Vara Prasad   +8 more
doaj   +1 more source

Grape vine (Vitis vinifera) yield prediction using optimized weighted ensemble machine learning approach

Smart Agricultural Technology
Grape vine (Vitis vinifera) plays a significant role in the agricultural industry, contributing substantially to the global economy through the production of table grapes, wine, and raisins.
Nobin Chandra Paul, Pratapsingh S. Khapte, Navyasree Ponnaganti, Sushil S. Changan, Sangram B. Chavan, K. Ravi Kumar, Dhananjay D. Nangare, K. Sammi Reddy   +7 more
doaj   +1 more source

Sexual Minority Women and Alcohol: Intersections between drinking, relational contexts, stress, and coping [PDF]

, 2011
Few studies explore sexual-minority women\u27s experiences and perceptions of alcohol. Qualitative interviews were conducted with six sexual-minority women who reported having sought help for alcohol problems in the past and six who did not.
Condit, M., Drabble, Laurie A, Kitaji, K., Trocki, K.   +3 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Melatonin improves high temperature stress tolerance by physiological and reproductive stabilization in common bean

Scientific Reports
The common bean is an essential legume crop that faces significant productivity threats from high temperature stress (HTS). It negatively impacts physio-biochemical processes, floral organ development, and fertilization, and degrades seed and nutritional
S. Kruthika, Apoorva Ashu, Amol P. Solanke, J. V. Navodhaya, C. Harimadhav, T. Basavaraja, Ajay Arora, Parvaze Sofi, Madan Pal, P Ratnakumar, P. V. Vara Prasad, S. Gurumurthy   +11 more
doaj   +1 more source

Stress Among Health Care Professionals - The Need for Resiliency [PDF]

, 2011
Healthcare professionals are subjected to considerable levels of stress such as work overload, excessive working hours, sleep deprivation, repeated exposure to emotionally charged situations, dealing with difficult patients and conflicts with other ...
Kakunje, Anil
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Ministry and stress : listening to Anglican clergy in Wales [PDF]

, 2011
This study set out to examine the experiences of stress in ministry among a sample of Anglican clergy serving in Wales. Building on recent quantitative studies of work-related psychological health among Anglican clergy in England, the study employed ...
Berry, Amanda, Francis, Leslie J., Rolph, Jenny, Rolph, Paul   +3 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source