Results 91 to 100 of about 915,307 (312)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Measuring Tourists' Stress in Colombia

Tourism: An International Interdisciplinary Journal, 2021
This research aims to examine vacationers’ perceived stress in Colombia. Based on the literature review, the following dimensions are examined: (1) transportation at the destination –including the variables lack of control, insecurity, cleanness, noise, temperature and space; (2) the conditions of the accommodation –including the variables lack of ...
openaire   +4 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Improved Use of Scatterometer Measurements by Using Stress-Equivalent Reference Winds

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2017
Numerical weather prediction (NWP) and buoy ocean surface winds show some systematic differences with satellite scatterometer and radiometer wind measurements, both in statistical results and in local geographical regions. It is possible to rescale these
Jos de Kloe, Ad Stoffelen, Anton Verhoef
doaj   +1 more source

Ministry and stress : listening to Anglican clergy in Wales [PDF]

, 2011
This study set out to examine the experiences of stress in ministry among a sample of Anglican clergy serving in Wales. Building on recent quantitative studies of work-related psychological health among Anglican clergy in England, the study employed ...
Paul Rolph, Rolph, Paul, Leslie J. Francis, Rolph, Jenny, Berry, Amanda, Jenny Rolph, Francis, Leslie J., Amanda Berry   +7 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Irrational beliefs in posttraumatic stress responses: A Rational Emotive Behaviour Therapy approach [PDF]

, 2015
The current study aimed to test a key theoretical prediction of Rational Emotive Behaviour Therapy theory by assessing the role of general and trauma-specific irrational beliefs in the prediction of posttraumatic stress responses.
Shevlin, Mark, Adamson, Gary, Hyland, Philip, Boduszek, Daniel   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Measuring acculturative stress with the SAFE: Evidence for longitudinal measurement invariance and associations with life satisfaction

, 2016
International graduate students in the U.S. (N = 468) completed the Social, Attitudinal, Familial, and Environmental Acculturative Stress Scale (SAFE; Mena, Padilla, & Maldonado, 1987) three times in successive semesters.
Rice, Kenneth G, Choi, Chun-Chung, Zhang, Yanmei, Anderson, Debra, Suh, Hanna, van Nuenen, Marieke, Morero, Yanina   +6 more
core   +1 more source