Results 121 to 130 of about 2,430,568 (285)
Full-field pulsed-magneto-photoelasticity - a description of the instrument
, 2006 This paper describes a novel instrument used for the analysis of full-field through-thickness stress distributions using the theory of magneto-photoelasticity (MPE) developed by Aben and Clarke et al. [ , , ].
Gibson, S. +2 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Development and Evaluation of a Multifrequency Ultrafast Doppler Spectral Analysis (MFUDSA) Algorithm for Wall Shear Stress Measurement: A Simulation and In Vitro Study. [PDF]
Diagnostics (Basel), 2023 Malone AJ +5 more
europepmc +1 more source
On the determination of flow stress using bulge test and mechanical measurement [PDF]
The standard uniaxial tensile test is a widely accepted method to obtain relevant properties of sheet metal materials. These fundamental parameters can be used in numerical modeling of sheet forming operations to predict and assess formability and ...
Barlat, F +3 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Applied SciencesWhen excavating roadways in underground mines, stress redistribution within the surrounding rock mass leads to stress concentration and release. Should the concentrated stresses exceed the rock mass’s tensile or shear strength, rock deformation and ...
Zongyong Wang +3 more
doaj +1 more source
Stress Measurement in Primary Care: Conceptual Issues, Barriers, Resources, and Recommendations for Study. [PDF]
Psychosom Med, 2022 Wulsin LR +7 more
europepmc +1 more source
Gear tooth stress measurements on the UH-60A helicopter transmission [PDF]
The U.S. Army UH-60A (Black Hawk) 2200-kW (3000-hp) class twin-engine helicopter transmission was tested at the NASA Lewis Research Center. Results from these experimental (strain-gage) stress tests will enhance the data base for gear stress levels in ...
Oswald, Fred B.
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source