Results 81 to 90 of about 2,430,568 (285)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Surface preparation for residual stress measurement of an accelerated corrosion tested welded marine steel [PDF]

open access: yes, 2015
Residual stress measurement is often required for the assessment of structural integrity of components. Measurement of residual stress in corrosion tested specimens is challenging owing to the difficulty of accessing the surface because of the rust layer.
Ahmed, Bilal, Fitzpatrick, Michael E.
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

High-sensitivity cardiac troponin T and copeptin assays to improve diagnostic accuracy of exercise stress test in patients with suspected coronary artery disease [PDF]

open access: yes, 2014
Background: The average diagnostic sensitivity of exercise stress tests (ESTs) is lower than that of other non-invasive cardiac stress tests. The aim of the study was to examine whether high-sensitivity cardiac troponin T (hs-cTnT) or copeptin ...
Dörr, Oliver   +9 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Biomarkers of oxidative stress: methods and measures of oxidative DNA damage (COMET assay) and telomere shortening [PDF]

open access: yes, 2008
Oxidative stress is fast becoming the nutritional and medical buzzword for the twenty-first century. The theoretical importance of oxidative stress in diabetes is highlighted by its potential double impact on metabolic dysfunction on one hand and the ...
A. Adaikalakoteswari   +15 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Ultrasonic measurement of stress in 2219-T87 aluminum plate [PDF]

open access: yes
The basic relationship of ultrasonic signal velocity to directional subsurface stress is reviewed. Inappropriateness of dependency on a single correlative value of constant for a three dimensional stress field in metallic materials is discussed ...
Clotfelter, W. N., Risch, E. R.
core   +1 more source

Stress and productivity patterns of interrupted, synergistic, and antagonistic office activities. [PDF]

open access: yes, 2019
We describe a controlled experiment, aiming to study productivity and stress effects of email interruptions and activity interactions in the modern office. The measurement set includes multimodal data for n = 63 knowledge workers who volunteered for this
Akbar, Fatema   +8 more
core   +1 more source

Shear thickening of cornstarch suspensions as a re-entrant jamming transition [PDF]

open access: yes, 2007
We study the rheology of cornstarch suspensions, a dense system of non-Brownian particles that exhibits shear thickening, i.e. a viscosity that increases with increasing shear rate.
Abdoulaye Fall   +6 more
core   +2 more sources

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