Results 51 to 60 of about 3,048,656 (303)

Association of PET-measured myocardial flow reserve with echocardiography-estimated pulmonary artery systolic pressure in patients with hypertrophic cardiomyopathy [PDF]

, 2019
BackgroundPulmonary hypertension (PH) is a known complication of HCM and is a strong predictor of mortality. We aim to investigate the relationship between microvascular dysfunction measured by quantitative PET and PH in HCM patients.MethodsEighty-nine ...
Leal, Jeffrey P, Liu, Min, Pomper, Martin G, Tsui, Benjamin M. W., Wong, Dean F, Zhao, Min, Zhou, Yun   +6 more
core   +3 more sources

True stress and Poisson's ratio of tendons during loading [PDF]

Journal of Biomechanics, 2011
Excessive axial tension is very likely involved in the aetiology of tendon lesions, and the most appropriate indicator of tendon stress state is the true stress, the ratio of instantaneous load to instantaneous cross-sectional area (CSA). Difficulties to measure tendon CSA during tension often led to approximate true stress by assuming that CSA is ...
Vergari, Claudio, Pourcelot, Philippe, Holden, Laurène, Ravary-Plumioën, Bérangère, Gerard, Guillaume, Laugier, Pascal, Mitton, David, Crevier-Denoix, Nathalie   +7 more
openaire   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

New model for surface fracture induced by dynamical stress

, 1997
We introduce a model where an isotropic, dynamically-imposed stress induces fracture in a thin film. Using molecular dynamics simulations, we study how the integrated fragment distribution function depends on the rate of change and magnitude of the ...
A. Groisman, A. J. Becker, A. Meibom, A. T. Skjeltorp, C. Allain, E. Namgoong, F. F. Abraham, G. Ouillon, J. V. Andersen, J. V. Andersen, J. V. Andersen, J.-C. Anifrani, Jørgen Vitting Andersen, K.-t. Leung, L. Oddershede, Laurent J. Lewis, M. P. Allen, O. Sotolongo-Costa, P. Meakin, R. L. B. Selinger, T. Ishii, T. Kadono, Z. Néda, Z. Zhou, Z.-G. Wang   +24 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A simple fatigue methodology for filled natural rubbers under positive and negative R ratios

Materials Research Express
This paper suggests a simple methodology to optimize the uniaxial fatigue predictions for filled natural rubbers. In this study, the stress ratio $R$ effect on rubber fatigue life is investigated numerically.
Salma Belkhiria, Anis Abroug, Raouf Fathallah   +2 more
doaj   +1 more source

Mechanical mechanism of in situ stress ratio limit and its evolution simulation

Frontiers in Earth Science, 2022
In situ stress is a natural phenomenon. According to the Mohr–Coulomb criterion, it is found that when the ratio of principal stress (the ratio of maximum principal stress to minimum principal stress) of crustal rock mass in a certain environment exceeds
Yifei Chen, Yifei Chen, Yongjian Wang, Fuqiong Huang, Long Ma, Changyi Yang, Haoyu Shi   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Research on Fatigue Crack Growth Rate Prediction of 2024-T3 Aluminum Alloy Friction Stir Welded Joints Driven by Machine Learning

Aerospace
Fatigue crack propagation in friction stir welded joints significantly affects aircraft structural integrity. This study investigates the influence of welding speed, rotational speed, specimen thickness, loading frequency, and stress ratio on the fatigue
Yanning Guo, Na Sun, Wenbo Sun, Xiangmiao Hao   +3 more
doaj   +1 more source