Results 71 to 80 of about 6,657,880 (307)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

True stress and Poisson's ratio of tendons during loading [PDF]

Journal of Biomechanics, 2011
Excessive axial tension is very likely involved in the aetiology of tendon lesions, and the most appropriate indicator of tendon stress state is the true stress, the ratio of instantaneous load to instantaneous cross-sectional area (CSA). Difficulties to measure tendon CSA during tension often led to approximate true stress by assuming that CSA is ...
Vergari, Claudio, Pourcelot, Philippe, Holden, Laurène, Ravary-Plumioën, Bérangère, Gerard, Guillaume, Laugier, Pascal, Mitton, David, Crevier-Denoix, Nathalie   +7 more
openaire   +3 more sources

Effects of inclusion size and stress ratio on fatigue strength for high-strength steels with fish-eye mode failure

, 2013
Experimental results indicate that the fatigue life reduces by about two orders of magnitude when inclusion size doubles. Then, a model is proposed for predicting the fatigue strength of high-strength steels with fish-eye mode failure based on the ...
Hong, YS (reprint author), Chinese Acad Sci, State Key Lab Nonlinear Mech, Inst Mech, Beijing 100190, Peoples R China., Lei ZQ(雷铮强), Sun CQ(孙成奇), Xie JJ(谢季佳), Hong YS(洪友士)   +4 more
core   +1 more source

True triaxial test and failure criterion of coal gangue concrete

Meitan xuebao
In view of the pollution caused by the large storage of coal gangue and the shortage of natural aggregate in concrete, using coal gangue as coarse aggregate is a reasonable way to solve the above problems.
Weiping ZHAO, Yuxiang HE, Kongliang JIANG, Jiaqi YANG, Yang XU, Jialong CHEN   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Thermally Induced Rock Stress Increment And Rock Reinforcement Response [PDF]

, 2016
The thermal heating caused by the deposition of spent nuclear fuel containers increases the in situ rock stress during disposal time. The thermal stress increase was modelled using thermo-mechanical modelling.
Hakala, Matti, Suikkanen, Johannes, Uotinen, Lauri, Nuijten, Guido, Siren, Topias, Ström, Jesse   +5 more
core   +1 more source

The Effect of Multiple Factors on the Fatigue Crack Growth Behavior of DH36 Steel in Arctic Environment

Journal of Marine Science and Engineering
In Arctic regions, ship structures face low temperatures, overloads, thickness effects, and fluctuating stress ratios, which significantly influence the fatigue crack growth (FCG) behavior of marine steels.
Kaiqing Qiao, Zhijie Liu, Zhenyu Sun, Qiuyu Guo, Xiaobang Wang   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Higher use of techniques studied and performance in melee combat produce a higher psychophysiological stress response [PDF]

, 2018
We aimed to analyse the effectiveness of an operative training in soldiers' psychophysiological and melee combat performance. Nineteen soldiers performed a 50-hr training for 10 weeks. After training, they were divided into two groups: higher performance
Diaz Manzano, Montaña, Clemente Suárez, Vicente Javier, Fernández Lucas, Jesús, Vicente Javier Clemente‐Suárez, Fuentes García, Juan Pedro, Aznar Lain, Susana, Susana Aznar‐Lain, Montaña Diaz‐Manzano, Fuentes, Juan Pedro, Juan P. Fuentes, Fuentes, Juan P., Jesús Fernandez‐Lucas   +11 more
core   +1 more source