Results 81 to 90 of about 3,073,145 (301)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Analisis potensi likuifaksi berdasarkan data penyelidikan tanah standard penetration test (SPT) (studi Kasus cross taxiway timur Bandara Soekarno Hatta Tangerang)

Teknika, 2020
Fenomena likuifaksi sering terjadi setelah kejadian gempa di beberapa tempat. Likuifaksi pada tanah dapat menyebabkan kerusakan yang parah bagi bangunan yang berada di atasnya, sehingga kerugian yang ditimbulkan sangat besar.
Enden Mina, Rama Indera Kusuma, Kiki Ariandhika Muzaky   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Fatigue Fracture Behaviors of Transparent Polycarbonate Materials

Cailiao gongcheng, 2017
The effect of the different stress ratios (R) and annealing treatment on the fatigue properties of the transparent polycarbonate (PC) sheet and the mechanism behind were studied, the fatigue crack propagation (FCP) process and mechanism were analyzed ...
ZHANG Xiao-wen, WU Nan, ZHANG Xuan, MA Li-ting, LI Lei   +4 more
doaj   +1 more source

Modelling the yield stress and the Poisson’s ratio of glassy polymers

e-Polymers, 2009
Abstract We have recently reported that the volumetric as well as the viscoelastic intricacies of mechanically stimulated glasses can be predicted by coupling the structural relaxation kinetics and viscoelastic response [1, 2, 3]. Here, it will be shown that our approach can be extended to predict the stressstrain ...
D'AMORE, Alberto, GRASSIA, Luigi, ACIERNO D.   +2 more
openaire   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fatigue Crack Propagation Property of YB-DM-10 Directional PMMA

Cailiao gongcheng, 2018
The threshold value of stress intensity factor range was acquired according the study of fatigue crack propagation property of directional PMMA (YB-DM-10).
ZHAO Jing-yun, Bamber BLACKMAN, YAN Yue, ZHANG Xuan, ZHANG Xiao-wen   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Fractographic Study on Naturally Initiated Short Fatigue Cracks in a Near-Lamellar TiAl Alloy at Room Temperature

Metals, 2019
Short crack phenomena are considered important for lamellar structures in γ-TiAl alloys and have been thoroughly investigated in the past. However, the short cracks in the previous studies were nearly all introduced artificially.
Shiyuan Wang, Yingzi Xi, Hangyue Li, Paul Bowen   +3 more
doaj   +1 more source