Results 91 to 100 of about 3,073,145 (301)

The Ratio of Working Stress to Allowable Stress of Structural Members of Wooden Houses II.

open access: yesMokuzai Gakkaishi, 2008
耐積雪等級が一般地域に建設された3棟の木造住宅の梁に生じる各種応力および最大たわみを算出し,許容応力度およびたわみ制限に対する負担率をそれぞれ求め,各梁において最大負担率を示す各応力・変形条件および荷重継続期間を調べた。その結果,以下の結論を得た。1)最大負担率が80%を越す例外的な梁もいくつか見られたが,平均すると約7割の梁は負担率が20%以下であり,強度的な余裕は充分にあった。2)小屋梁の多くでは「最大たわみ」によって最大負担率が決定する傾向があった。これは,小屋梁に断面の小さい梁を用いることが居住性に悪影響をもたらす訳ではないため,設計者が経済的な有利さを考慮してそれらを選択したと推察される。3)梁のスパン中間に上階の耐力壁が下階の柱無しに載ることにより,強度的に余裕が乏しい梁も存在しうる ...
Hideki Aoi   +3 more
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

An improved method for obtaining a normalized junction temperature for semiconductors: A concept [PDF]

open access: yes, 1973
Failure rate for given semiconductor device is simply determined by reading value of normalized junction temperature from printout for any given combination of ambient temperature, stress ratio, and maximum rated junction temperature, and obtaining ...
Trivedi, S. N.
core   +1 more source

New model for surface fracture induced by dynamical stress

open access: yes, 1997
We introduce a model where an isotropic, dynamically-imposed stress induces fracture in a thin film. Using molecular dynamics simulations, we study how the integrated fragment distribution function depends on the rate of change and magnitude of the ...
A. Groisman   +24 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Influence of linear profile modification and loading conditions on the dynamic tooth load and stress of high contact ratio gears [PDF]

open access: yes
A computer simulation for the dynamic response of high-contact-ratio spur gear transmissions is presented. High contact ratio gears have the potential to produce lower dynamic tooth loads and minimum root stress but they can be sensitive to tooth profile
Lee, Chinwai   +3 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

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