Results 111 to 120 of about 8,553,788 (398)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

The etiology of oxidative stress in insulin resistance

Biomedical Journal, 2017
Insulin resistance is a prevalent syndrome in developed as well as developing countries. It is the predisposing factor for type 2 diabetes mellitus, the most common end stage development of metabolic syndrome in the United States. Previously, studies investigating type 2 diabetes have focused on beta cell dysfunction in the pancreas and insulin ...
Samantha Hurrle, Walter H. Hsu
openaire   +4 more sources

ZmHPAT2 Regulates Maize Growth and Development and Mycorrhizal Symbiosis

Plants
Hydroxyproline O-arabinosyltransferase (HPAT), a critical enzyme in plant glycosylation pathways, catalyzes the transfer of arabinose to the hydroxyl group of hydroxyproline residues.
Kailing Xie, Guoqing Wang, Ying Ni, Minghui Shi, Lixue Sun, Beijiu Cheng, Xiaoyu Li   +6 more
doaj   +1 more source

Nickel-base alloy containing Mo-W-Al-Cr- Ta-Zr-C-Nb-B Patent [PDF]

, 1966
Nickel base alloy with resistance to oxidation at high temperatures and superior stress-rupture ...
Freche, J. C., Waters, W. J.
core   +1 more source

Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans

Scientific Reports, 2017
Bacteria naturally form communities of cells known as biofilms. However the physiological roles of biofilms produced by non-pathogenic microbiota remain largely unknown.
O. Smolentseva, I. Gusarov, L. Gautier, Ilya Shamovsky, A. S. DeFrancesco, R. Losick, E. Nudler   +6 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Genome-Wide Identification, Characterization, and Expression Profile of SWEETs Gene Family in Grapevine (Vitis vinifera L.)

Horticulturae
SWEET (Sugars Will Eventually Be Exported Transporter) proteins, identified recently as a novel class of sugar transporters, play pivotal roles in the transport and distribution of photosynthetic products in plants.
Linjing Zhong, Shuya Xu, Chenchen Song, Ning Zhao, Zhiqi Yang, Yanxiang Liu, Xiaoyue Cui, Jianxia Zhang, Zhi Li, Xiping Wang, Min Gao   +10 more
doaj   +1 more source

Effect of aspartic acid and glutamate on metabolism and acid stress resistance of Acetobacter pasteurianus

Microbial Cell Factories, 2017
BackgroundAcetic acid bacteria (AAB) are widely applied in food, bioengineering and medicine fields. However, the acid stress at low pH conditions limits acetic acid fermentation efficiency and high concentration of vinegar production with AAB. Therefore,
Haisong Yin, Renkuan Zhang, Menglei Xia, Xiaolei Bai, J. Mou, Yu Zheng, Min Wang   +6 more
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

AcNAC10, regulated by AcTGA07, enhances kiwifruit resistance to Pseudomonas syringae pv. actinidiae via inhibiting jasmonic acid pathway

Molecular Horticulture
Kiwifruit bacterial canker is a devastating disease caused by Pseudomonas syringae pv. actinidiae (Psa). NAC transcription factors play a significant role in host immunity.
Chao Zhao, Wei Liu, Chenxiao Yao, Yali Zhang, Xiaofei Du, Chao Ma, Rui Li, Hua Wang, Lili Huang   +8 more
doaj   +1 more source