Results 121 to 130 of about 2,387,231 (339)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Crop JournalGTs (Glycosyltransferases) are important in plant growth and abiotic stresses. However, its role in maize heat response is far from clear. Here, we describe the constitutively expressed UDP-glycosyltransferase ZmUGT92A1, which has a highly conserved PSPG
Hao Li +6 more
doaj +1 more source
Governance, performance, and chronic capacity stress in public policy systems [PDF]
, 2013 Public policy systems often betray signs of capacity stress. Supply factors seem to lag behind demand, and as a result these systems sustain what appears to be chronically sub-optimal performance neither completely excelling nor completely failing in ...
Bastow, Simon
core
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Stress BiologyMetalloproteinases are ubiquitous in organisms. Most metalloproteinases secreted by pathogenic microorganisms are also called virulence factors, because they degrade proteins in the external tissues of the host, thereby reducing the host’s immunity and ...
Xin-tong Wang +5 more
doaj +1 more source
Identification and analysis of factors affecting thermal shock resistance of ceramic materials in solar receivers [PDF]
An analysis was conducted of the possible modes of thermal stress failure of brittle ceramics for potential use in point-focussing solar receivers. The pertinent materials properties which control thermal stress resistance were identified for conditions ...
Hasselman, D. P. H. +2 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Identification and characterization of grape VAP27 gene family and their roles in disease resistance
Fruit ResearchVesicle-associated membrane protein (VAMP)-associated proteins (VAP27s), which are widely expressed in plants and animals, play an important role in metabolism, physiology, growth, and development, disease resistance, and immunity.
Ruonan Li +8 more
doaj +1 more source
Controlling stress corrosion cracking in mechanism components of ground support equipment [PDF]
The selection of materials for mechanism components used in ground support equipment so that failures resulting from stress corrosion cracking will be prevented is described.
Majid, W. A.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source