Results 171 to 180 of about 2,337,821 (336)

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Haplotype-resolved telomere-to-telomere genome assembly of the dikaryotic fungus pathogen Rhizoctonia cerealis

Scientific Data
Rhizoctonia cerealis, the causal agent of sharp eyespot, is a highly destructive pathogen of wheat. Despite its global importance, the genetic and molecular mechanisms underlying virulence of R. cerealis remain poorly understood. R.
Jiang-Na Han, Yu Li, Wei Li, Hao-Hao Yan, Fengping Yuan, Huai-Gu Chen, De-Jun Han, Zhen-Sheng Kang, Qing-Dong Zeng   +8 more
doaj   +1 more source

Water Potential and Stomatal Resistance of Sunflower and Soybean Subjected to Water Stress during Various Growth Stages

, 1976
Nasser Sionit, Paul J. Kramer
openalex   +2 more sources

Effect of exposure cycle on hot salt stress corrosion of a titanium alloy [PDF]

The influence of exposure cycle on the hot-salt stress-corrosion cracking resistance of the Ti-8Al-1Mo-1V alloy was determined. Both temperature and stress were cycled simultaneously to simulate turbine-powered aircraft service cycles.
Gray, H. R., Johnston, J. R.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Varietal Differences in Leaf Water Potential, Leaf Diffusive Resistance and Grain Yield of Grain Sorghum Affected by Drought Stress

, 1978
Shigeru INUYAMA
openalex   +2 more sources

Resistance to thermal stress in preadult Drosophila buzzatii: variation among populations and changes in relative resistance across life stages [PDF]

, 1995
Robert A. Krebs, Volker Loeschcke
openalex   +1 more source

Breeding for stress resistance in legumes

, 2013
Comunicación presentada en la First Legume Society Conference, celebrada en Novi Sad (Serbia) del 9 al 11 de mayo de 2013.
Rubiales, Diego, Barilli, Eleonora, Rispail, Nicolas, Prats, Elena, Fernández-Aparicio, Mónica, Castillejo Sánchez, M. Ángeles, Iglesias-García, Rebeca, Fondevilla, Sara   +7 more
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies

Molecular Oncology, EarlyView.
RAS‐targeted therapies have become a clinical reality. Although promising results in patients have been achieved, there are still challenges ahead such as coping with drug resistance. Here we summarize selected RAS inhibitors targeting either individual KRAS mutant isoforms (KRASG12C, KRASG12D, KRASG12V) or exhibiting a wider inhibitory spectrum ...
Matthias Drosten, Mariano Barbacid
wiley   +1 more source