Results 81 to 90 of about 2,387,231 (339)

N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance [PDF]

, 2020
Noa Liberman, Zach Klapholz O’Brown, Andrew Earl, Konstantinos Boulias, Maxim V. Gerashchenko, Simon Yuan Wang, Colette Fritsche, Paul-Enguerrand Fady, Anna Dong, Vadim N. Gladyshev, Eric Lieberman Greer   +10 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

ClPS1 gene-mediated manipulation of 2n pollen formation enables the creation of triploid seedless watermelon

Molecular Horticulture
Seedless watermelons are increasingly dominating the consumer market due to their convenience and high quality. However, traditional triploid watermelon breeding faces challenges such as long breeding cycles and low survival rates of triploid F1 progeny,
Wenyu Pang, Qiaran Wang, Chenxin Li, Wenbing He, Jiafa Wang, Shujuan Tian, Li Yuan   +6 more
doaj   +1 more source

Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extremely poor prognosis. The standard chemotherapeutic drug, gemcitabine, does not offer significant improvements for PDAC management due to the rapid acquisition of drug resistance by patients.
Bielli, Pamela, Capurso, Gabriele, Delle Fave, Gianfranco, Farini, Donatella, Panzeri, Valentina, Passacantilli, Ilaria, Pilozzi, Emanuela, Sette, Claudio   +7 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Stanovení nejistoty měření přetvoření a mechanického napětí získané z odporových tenzometrů [PDF]

, 2017
The article deals with the determination of measurement uncertainty of strain and stress using resistance strain gages. You can find two methods to define the uncertainty in the article, GUF and MMC, and both are applied for measurements carried out with
Dokoupil, Pavel
core   +1 more source

Randomized Double Blind Clinical Trial Evaluating the Ellagic Acid Effects on Insulin Resistance, Oxidative Stress and Sex Hormones Levels in Women With Polycystic Ovarian Syndrome [PDF]

, 2021
Mahnaz Kazemi, Fatemeh Lalooha, Mohammadreza Rashidi Nooshabadi, Fariba Dashti, Maria Kavianpour, Hossein Khadem Haghighian   +5 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Functional Characterization of Ammonium Transporter LjAMT2;4 During Lotus japonicus Symbiosis with Rhizobia and Arbuscular Mycorrhizal Fungi

Journal of Fungi
Arbuscular mycorrhizal fungi (AMF) and rhizobia are important symbiotic microorganisms in soil, which can symbiose with legumes to form mycorrhizal symbionts and nodules, respectively.
Kailing Xie, Ying Ni, Lijie Bai, Yuqian Zhai, Wenqing Zhou, Beijiu Cheng, Xiaoyu Li   +6 more
doaj   +1 more source

Crack path selection at the interface of wrought and wire+arc additive manufactured Ti–6Al–4V [PDF]

, 2016
Crack propagation deviation tendency in specimens containing an interface between wrought alloy substrate and Wire + Arc Additive Manufacture (WAAM) built Ti–6Al–4V is investigated from the viewpoints of microstructure, residual stress and bi-material ...
Addison, Antonysamy, Antonysamy, ASTM, Baufeld, Baufeld, Brandl, Brandl, Colegrove, Dahlin, Dattoma, Ding, Edwards, Edwards, Edwards, Evans, Fan, Frazier, Hills, Irwin, Kelly, Leuders, Lorant, Martina, Mok, Nègre, Paradowska, Peters, Pippan, Prime, Prime, Rangaswamy, Schroeder, Taminger, Van Hooreweder, Wang, Wang, Zhang, Zhang, Zhu   +39 more
core   +3 more sources