Results 111 to 120 of about 4,861,401 (308)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Comparison of Microtubule Organization in Arabidopsis thaliana TUBGFP and MBD-GFP Mutants Exposed to UV-B Radiation

Journal of Agricultural Sciences, 2017
Microtubule organization was compared between the Arabidopsis thaliana TUB-GFP and MBD-GFP mutants. Plant height and primary root length were measured, and microtubule dynamics were examined by confocal laser scanning microscopy after UV-B radiation to ...
Dongjing Ma, Huize Chen, Rong Han
doaj   +1 more source

MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock [PDF]

, 2014
Background: MAPK-activated protein kinase 2 (MK2) plays a pivotal role in the cell response to (inflammatory) stress. Among others, MK2 is known to be involved in the regulation of cytokine mRNA metabolism and regulation of actin cytoskeleton dynamics ...
Brouckaert, Peter, Cauwels, Anje, Goethals, An, Simats, Alba, Van Hamme, Evelien, Vandendriessche, Benjamin   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Quorum Sensing-Regulated Phenol-Soluble Modulins Limit Persister Cell Populations in Staphylococcus aureus

Frontiers in Microbiology, 2018
Incomplete killing of bacterial pathogens by antibiotics is an underlying cause of treatment failure and accompanying complications. Among those avoiding chemotherapy are persisters being individual cells in a population that for extended periods of time
Martin S. Bojer, Martin S. Bojer, Søren Lindemose, Martin Vestergaard, Hanne Ingmer, Hanne Ingmer   +5 more
doaj   +1 more source

On piezophase effects in mechanically loaded atomic scale Josephson junctions

, 1998
The response of an intrinsic Josephson contact to externally applied stress is considered within the framework of the dislocation-induced atomic scale Josephson effect.
Chisholm M, Cottrell A H, Koch C, Kovalyova V N, S Sergeenkov, Tsu I F   +5 more
core   +1 more source

A biologically relevant rapid quantification of physical and biological stress profiles on rocky shores. [PDF]

, 2014
Different combinations and intensities of physical (e.g. thermal) and biological (e.g.competition or predation) stress operate on organisms in different locations. Variation in these stresses can occur over small to medium spatial scales (cm to 10s m) in
Allcock, Ayre, Baker, Benedetti-Cecchi, Bohnsack, Braunisch, Catlin-Groves, Chapperon, Colman, Costantini, Denny, Diamond, Efron, Garrity, Gillingham, Gillingham, Gray A. Williams, Halpin, Harley, Harley, Hawkins, Helaouët, Helmuth, Hoskin, Hutchinson, Kearney, Krueger-Hadfield, Leibold, Lubchenco, Mark S. Davies, Menge, Menge, Menge, Ngan, Norton, Paine, Pechenik, Peterson, Richard Stafford, Sagarin, Sarà, Somero, Stafford, Stafford, Stafford, Tabachnick, Terence P.T. Ng, Underwood, Underwood, van Straalen, Williams, Williams, Williams, Wolcott, Wooton   +54 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila [PDF]

, 2008
Apolipoprotein D (ApoD) expression increases in several neurological disorders and in spinal cord injury. We provide a report of a physiological role for human ApoD (hApoD): Flies overexpressing hApoD are long-lived and protected against stress ...
Ahn, Boyles, Boyles, Butterfield, D. W. Walker, Desai, Do Carmo, Duffy, Guti  rrez, J. Muffat, Kalman, Lechner, Morais Cabral, Navarro, Oakley, Pfaffl, Provost, Provost, Rassart, S. Benzer, Sanchez, Sutcliffe, Terrisse, Thomas, Thomas, Toroser, Vogt, Walker, Wallace, Walsh, Weech   +30 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source