Results 61 to 70 of about 2,550,820 (307)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

SaaS Infrastructure as a Means of DDoS-amplification

Безопасность информационных технологий, 2014
Any online project – be it a long-lost blog, or a new start-up’s web app – has a very important performance feature called a “maximum load”. This indicator makes itself known when a web app either partially or fully fails to perform its assigned ...
Denis Nikolaevich Makrushin
doaj  

Integrated Application of Navier–Stokes, Ricci Flow, and EVA Frameworks for Modelling Systemic Risks, Shock Scenarios, and Resilience to Socioeconomic Challenges: The Case of Critical Railway Corridors [PDF]

SocioEconomic Challenges
The paper presents a multifaceted analysis of the strategic impact of the Georgian railway corridor on the country’s economic development through an innovative synthesis of physical, mathematical, and financial modeling frameworks.
Davit Gondauri, Nino Chedia
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Systematic approach to develop and validate High Performance Liquid Chromatographic method for efavirenz and its degradants

Journal of Applied Pharmaceutical Research
Background: The crucial aspect to consider during method development and validation, ensuring accurate, precise, and specific estimation of drug substances and drug products, is stability.
Sudhir Kumar Sahoo, Prasanta Kumar Choudhury, P N Murthy, Uma Shankar Mishra, Saroj Kanta Bisoyi, Lokesh Kumar   +5 more
doaj   +1 more source

Applying stress-testing on value at risk (VaR) methodologies [PDF]

, 2004
In recent years, Value at Risk (VaR) methodologies, i. e., Parametric VaR, Historical Simulation and the Monte Carlo Simulation have experienced spectacular growth within the new regulatory framework which is Basle II.
Feria Domínguez, José Manuel, Oliver Alfonso, María Dolores   +1 more
core   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

New Approaches to Stress Testing the Czech Banking Sector (in English) [PDF]

This paper provides an overview of the stress testing of the Czech banking sector conducted by the Czech National Bank. The paper begins by updating historical and hypothetical stress-testing scenarios.
Jaroslav HEØMÁNEK, Martin ÈIHÁK, Michal HLAVÁÈEK   +2 more
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Stress Testing and Corporate Finance. [PDF]

The article contributes to the literature on financial fragility, studying how macro-economic shocks affect supply and demand in the corporate debt market.
Bruneau, C., De Bandt, O., El Amri, W.
core