Results 71 to 80 of about 2,550,820 (307)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Bank Stress Testing: A Stochastic Simulation Framework to Assess Banks’ Financial Fragility †

open access: yesRisks, 2018
We present a stochastic simulation forecasting model for stress testing that is aimed at assessing banks’ capital adequacy, financial fragility, and probability of default.
Giuseppe Montesi, Giovanni Papiro
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Stress-Induced Magnetic Anisotropy Model Under Unidirectional Tension

open access: yesIEEE Access, 2020
In this paper, we theoretically investigated stress-induced magnetic anisotropy and presented a model based on a unidirectional tensile stress experiment. Firstly, the theoretical model was simulated based on the work of Jiles. Secondly, experiments were
Fuchen Zhang   +3 more
doaj   +1 more source

The relationship between default and economic cycles for retail portfolios across countries

open access: yes, 2008
In this paper, we collect consumer delinquency data from several economic shocks in order to study the creation of stress-testing models. We leverage the dual-time dynamics modeling technique to better isolate macroeconomic impacts whenever vintage-level
Breeden, J.L., Thomas, Lyn C.
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Development of methodological tools to build a portfolio of innovation dominant company on the basis of an evaluation of promising innovative semis

open access: yesПутеводитель предпринимателя, 2020
The paper developed an approach to the evaluation of promising innovative semifinished products by conducting innovative filtration semis at different stages ofvalue chain innovation and evolutionary modeling, which allows to determine the compliance of ...
A. V. Bandurin, E. Yu. Kamchatova
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Assessment of systemic financial risks

open access: yesПутеводитель предпринимателя, 2020
The article is devoted to assessment of systemic financial risks as an important stage of global governance of systemic financial risks. The article considers such evaluation methods as stress testing, computing of financial stress indices, indicators of
O. V. Savvina
doaj  

Stress Testing of Probability of Default of Individuals [PDF]

open access: yes
This paper introduces a model for stress testing of probability of default of individuals. The model rests on assumption that the individual defaults if his savings fall below zero.
Aleš Slabý   +2 more
core   +1 more source

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