Results 81 to 90 of about 527,120 (313)

Breeding drought tolerant cowpea: constraints, accomplishments, and future prospects

, 2009
This review presents an overview of accomplishments on different aspects of cowpea breeding for drought tolerance. Furthermore it provides options to enhance the genetic potential of the crop by minimizing yield loss due to drought stress. Recent efforts
Visser, R.G.F., Muranaka, S., Agbicodo, A.C.M.E., Linden, C.G., van der, Fatokun, C.A.   +4 more
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Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Genetics and Genomics of Stomatal Traits for Improvement of Abiotic Stress Tolerance in Cereals

, 2019
In traditional breeding programmes for improving abiotic stress tolerance of cereals , direct selection for grain yield is slow and costly, requiring many years and sites of field trials.
Mohammad-Reza Hajirezaei, Penny J. Tricker, Shahinnia, Fahimeh, Chen, Zhonghua (R16781), Tricker, Penny J., Hajirezaei, Mohammad-Reza, Fahimeh Shahinnia, Zhonghua Chen   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Breeding Perennial Species for Abiotic Stress

, 2012
In agriculture, the term stress is understood to mean any factor, whether biotic or abiotic, that is detrimental to the growth and productivity of plants.
Celso Luis Marino, De Paula, Nadia Figueiredo, Rinaldo Cesar de Paula, Nadia Figueiredo de Paula, Marino, Celso Luis [UNESP], De Paula, Rinaldo Cesar [UNESP]   +5 more
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Role of Oxidative Stress in Persister Tolerance [PDF]

Antimicrobial Agents and Chemotherapy, 2012
ABSTRACT Persisters are dormant phenotypic variants of regular cells that are tolerant to antibiotics and play an important role in recalcitrance of chronic infections to therapy. Persisters can be produced stochastically in a population untreated with antibiotics.
Yanxia, Wu, Marin, Vulić, Iris, Keren, Kim, Lewis   +3 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

GenoTypeMapper: graphical genotyping on genetic and sequence-based maps

Plant Methods, 2020
Background The rising availability of assemblies of large genomes (e.g. bread and durum wheat, barley) and their annotations deliver the basis to graphically present genome organization of parents and progenies on a physical scale.
Mathieu Deblieck, Andrii Fatiukha, Norbert Grundman, Lianne Merchuk-Ovnat, Yehoshua Saranga, Tamar Krugman, Klaus Pillen, Albrecht Serfling, Wojciech Makalowski, Frank Ordon, Dragan Perovic   +10 more
doaj   +1 more source

Unravelling salt stress tolerance: physiological, morphological and genetic components in crop species and model plants

, 2008
This PhD Thesis address fundamental mechanisms of salt stress response in plants from an agronomic, physiological, morphological and genetic point of view. Specifically we considered salt stress tolerance performances of eleven wild species of Cruciferae,
Orsini, Francesco
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