Results 61 to 70 of about 2,718,585 (285)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Screening Oat Genotypes for Tolerance to Salinity and Alkalinity

Frontiers in Plant Science, 2018
A set of four experiments was conducted to develop methods for screening oat tolerance to salt and alkali and the following results were obtained.
Jianhui Bai, Jianhui Bai, Weikai Yan, Yuqing Wang, Qiang Yin, Jinghui Liu, Charlene Wight, Baoluo Ma   +7 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Wheat improvement for nutritional quality and abiotic stress tolerances

Discover Plants
Hunger, malnutrition, and climate change (CC) are the prime concerns impacting a substantial fraction of the world’s population. Wheat is one of the notable staple foods imperatives for supporting global food and nutrition security.
Debanjana Saha, Krishna Mishra, Chinmayee Pattnayak, Prajjal Dey, Mahendra Singh, Monika Yadav, Chitrangna Singh, Rajesh Kumar Singhal   +7 more
doaj   +1 more source

Autophagy, a conserved mechanism for protein degradation, responds to heat and other abiotic stresses in Capsicum annuum L.

Frontiers in Plant Science, 2016
Abiotic stresses negatively affect plants growth and development by inducing protein denaturation, and autophagy degrades the damaged proteins to alleviate their toxicity, however, little is known about the involvement of autophagy in pepper (Capsicum ...
Yufei eZhai, Meng eGuo, Hu eWang, Jinping eLu, Jinhong eLiu, Chong eZhang, Zhen-Hui eGong, Minghui eLu   +7 more
doaj   +1 more source

Heterologous Expression of Three Ammopiptanthus mongolicus Dehydrin Genes Confers Abiotic Stress Tolerance in Arabidopsis thaliana

Plants, 2020
Ammopiptanthus mongolicus, a xerophyte plant that belongs to the family Leguminosae, adapts to extremely arid, hot, and cold environments, making it an excellent woody plant to study the molecular mechanisms underlying abiotic stress tolerance.
Hongwei Cui, Yang Wang, Tingqiao Yu, Shaoliang Chen, Yuzhen Chen, Cunfu Lu   +5 more
doaj   +1 more source

Salinity Stress and Salt Tolerance

, 2011
Salinity is one of the most serious factors limiting the productivity of agricultural crops, with adverse effects on germination, plant vigour and crop yield (R Munns & Tester, 2008). Salinization affects many irrigated areas mainly due to the use of brackish water.
CARILLO P, ANNUNZIATA M. G, PONTECORVO, Giovanni, FUGGI A, WOODROW P   +4 more
openaire   +3 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Mechanisms and evolution of resistance to environmental extremes in animals

EvoDevo, 2019
When animals are exposed to an extreme environmental stress, one of three possible outcomes takes place: the animal dies, the animal avoids the environmental stress and survives, or the animal tolerates the environmental stress and survives.
Thomas C. Boothby
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source