ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Southern hemisphere ceratosaurs evolved feeding mechanics paralleling those of Northern hemisphere tyrannosaurids. [PDF]
Rowe AJ, Cerroni MA, Rayfield EJ.
europepmc +1 more source
The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source
The ERF Transcription Factor <i>ERF41</i> Negatively Regulates Drought and Salt Tolerance in <i>Arabidopsis thaliana</i>. [PDF]
Wang J, Luo M, Xiao H, Zhang Y.
europepmc +1 more source
From Shared Mechanisms to Precision Breeding: Engineering Cold and Drought Cross-Tolerance in Crops. [PDF]
Yang X +6 more
europepmc +1 more source
Experimental Assessment of Stress-Strain Response in Filament-Wound GFRP Pipes Under Internal Pressure Loading. [PDF]
Ilincă CN +8 more
europepmc +1 more source
Pan-genomic analysis and abiotic stress expression of eight TPS gene families in Brassica napus. [PDF]
Xue T +7 more
europepmc +1 more source
Comparative Analysis of the Application of Five-, Seven- and Nine-Roll Sheet Straightening Using Numerical Tools. [PDF]
Stradomski G +5 more
europepmc +1 more source
Influence of Rolling Direction on Barkhausen Noise in Low-Alloyed Steel MC500. [PDF]
Koňár R +5 more
europepmc +1 more source

