Results 71 to 80 of about 1,921,038 (288)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Magnetic Stress at the Marginally Stable Orbit: Altered Disk Structure, Radiation, and Black Hole Spin Evolution

open access: yes, 1999
Magnetic connections to the plunging region can exert stresses on the inner edge of an accretion disk around a black hole. We recompute the relativistic corrections to the thin-disk dynamics equations when these stresses take the form of a time-steady ...
Agol E.   +9 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural behavior of a flexible pavement, stresses, deformations and deflections

open access: yesRevista Ingenio, 2013
This research work was carried out with the support of the Research Division of the Pedagogical and Technological University of Colombia and shows the behavior of stress states: forces, deformations and deflections acting on a flexible pavement structure.
Carlos Hernando Higuera Sandoval
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

CFD-FEM Analysis for Functionality Prediction of Multi-Gear Pumps

open access: yesDesigns
A comprehensive model for evaluating the functionality of a multi-gear pump has been developed. The integrated model for assessing the functionality of a multi-gear pump contains a computational fluid dynamics analysis (CFD) model combined with a finite ...
Olga Zharkevich   +6 more
doaj   +1 more source

Two-dimensional thermo-viscoelastic waves in layered media

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2019
Dynamic problems of deformation of solids have been the subject of numerous studies in the CIS and abroad. The rejection of a number of simplifying assumptions made in the cited and other published works leads to the need for further refinement and ...
M.M. Bukenov   +2 more
doaj   +1 more source

Investigation of the features of the load transfer process in ordinary rock structures

open access: yesТехнічна інженерія, 2020
The necessity of further development or improvement of protective equipment based on the use of ordinary rock with special design features for effective maintenance of preparatory workings behind stoping face during underground coal mining in the ...
S.H. Nehrii
doaj   +1 more source

Modeling and Optimal Design of Machining-Induced Residual Stresses in Aluminium Alloys Using a Fast Hierarchical Multiobjective Optimization Algorithm [PDF]

open access: yes, 2011
The residual stresses induced during shaping and machining play an important role in determining the integrity and durability of metal components. An important issue of producing safety critical components is to find the machining parameters that create ...
Christophe Pinna   +10 more
core   +1 more source

Oxidative stress

open access: yesBest Practice & Research Clinical Obstetrics & Gynaecology, 2011
Considerable evidence implicates oxidative stress in the pathophysiology of many complications of human pregnancy, and this topic has now become a major focus of both clinical and basic science research. Oxidative stress arises when the production of reactive oxygen species overwhelms the intrinsic anti-oxidant defences.
Burton, Graham J., Jauniaux, Eric
openaire   +2 more sources

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