Results 91 to 100 of about 1,937,011 (307)

Pavement stresses due to tire impact [PDF]

, 1995
Road surfaces wear continually under the effects of vehicular motions in an environment of changing temperature, humidity, etc. Regulatory agencies need to set limits on vehicular loads, tire pressures, etc., in order to mitigate the damage caused by the
Cumberbatch, E., Schichtel, M.
core  

Residual Stresses Induced by Dry and Cryogenic Cooling during Machining of AZ31B Magnesium Alloy [PDF]

, 2014
The major challenge of the Mg alloys has been their unsatisfactory corrosion resistance, which can be enhanced by improving the surface integrity. Cryogenic machining, where liquid nitrogen was used during machining, has been reported to improve the ...
BATISTA, Antonio, MARQUES, M.J., OUTEIRO, José   +2 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Radiating Collapse with Vanishing Weyl stresses

, 2004
In a recent approach in modelling a radiating relativistic star undergoing gravitational collapse the role of the Weyl stresses was emphasised. It is possible to generate a model which is physically reasonable by approximately solving the junction ...
Goswami R., M. GOVENDER, S. D. MAHARAJ
core   +1 more source

STRESS ECHOCARDIOGRAPHY

International Journal of Clinical Practice, 1997
SUMMARY Stress echocardiography has a number of advantages over exercise electrocardiography. It has superior sensitivity and specificity as it detects wall motion abnormalities, an earlier and more specific marker for myocardial ischaemia than ST segment depression. It can also localise ischaemia and identify hibernating myocardium.
M B, Mishra, J B, Chambers
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Stress-Induced Sulfide Production by Bacillus subtilis and Bacillus megaterium

Microorganisms
It was previously discovered that, in the Gram-negative bacterium Escherichia coli growing on a minimal medium with sulfate, stress-induced growth arrest is accompanied by the release of hydrogen sulfide.
Alexey Tyulenev, Galina Smirnova, Vadim Ushakov, Tatyana Kalashnikova, Lyubov Sutormina, Oleg Oktyabrsky   +5 more
doaj   +1 more source

Thermomechanical behavior of plasma-sprayed ZrO2-Y2O3 coatings influenced by plasticity, creep and oxidation [PDF]

Thermocycling of ceramic-coated turbomachine components produces high thermomechanical stresses that are mitigated by plasticity and creep but aggravated by oxidation, with residual stresses exacerbated by all three. These residual stresses, coupled with
Chung, B. T. F., Hendricks, Robert C., Mcdonald, Glen E., Padovan, J.   +3 more
core   +1 more source