Results 71 to 80 of about 905,110 (306)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
CFD-FEM Analysis for Functionality Prediction of Multi-Gear Pumps
DesignsA comprehensive model for evaluating the functionality of a multi-gear pump has been developed. The integrated model for assessing the functionality of a multi-gear pump contains a computational fluid dynamics analysis (CFD) model combined with a finite ...
Olga Zharkevich +6 more
doaj +1 more source
Two-dimensional thermo-viscoelastic waves in layered media
Қарағанды университетінің хабаршысы. Математика сериясы, 2019 Dynamic problems of deformation of solids have been the subject of numerous studies in the CIS and abroad. The rejection of a number of simplifying assumptions made in the cited and other published works leads to the need for further refinement and ...
M.M. Bukenov +2 more
doaj +1 more source
Investigation of the features of the load transfer process in ordinary rock structures
Технічна інженерія, 2020 The necessity of further development or improvement of protective equipment based on the use of ordinary rock with special design features for effective maintenance of preparatory workings behind stoping face during underground coal mining in the ...
S.H. Nehrii
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Modeling of thermal stresses in low alloy steels
, 2019 Computing the evolution of thermal stresses accurately requires appropriate constitutive relations. This includes both the thermal and mechanical aspects, as temperature is the driver to thermal stresses.
Lindgren, Lars-Erik, +3 more
core +1 more source
Measurement and modelling of the transient thermal-mechanical strain field during GMA welding [PDF]
, 2011 The state of residual stress in welded joints is a well-studied topic, and many methodsof residual stress measurement are now available. However, far less is known aboutthe transient strains which occur during the welding process, even though these ...
Colegrove, Paul A. +3 more
core +4 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
ALGORITHM FOR MODELING THE STRESS-DEFORMED STATE OF BENDED-RIGID THREADS
Модели, системы, сети в экономике, технике, природе и обществе, 2022 Background. An algorithm is proposed for modeling the distribution of stresses and strains, taking into account the bending stiffness in elements for which the design model is a thread. Materials and methods.
D.A. Tarasov +2 more
doaj +1 more source