Results 131 to 140 of about 4,593,130 (335)

Coping Difficulties After Hospitalization [PDF]

, 2008
Coping difficulties of 113 adults 3 weeks after hospital discharge were identified using the Post-Discharge Coping Difficulty Scale and a brief focused telephone interview (11-item guide). Overall, low difficulty scores were reported (M = 23.9, SD = 18.2,
Miller, Judith Fitzgerald, Piacentine, Linda, Weiss, Marianne   +2 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Clinical Education Stressors from the Perspective of Students of Nursing, Midwifery, and Operating Room: A Study in Kurdistan University of Medical Sciences [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2012
Introduction: Continuous investigation of educational stressors, and managing them is essential for quality improvement of clinical education. This study investigated stressors of clinical education from the perspective of nursing, midwifery and ...
golrokh moridi, sina valiee, shahnaz khaledi, Mohammad Fathi, Majid Shafiean, Fardin Gharibi,   +6 more
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Assessing habitat risk from human activities to inform coastal and marine spatial planning: a demonstration in Belize

Environmental Research Letters, 2014
Integrated coastal and ocean management requires transparent and accessible approaches for understanding the influence of human activities on marine environments.
Katie K Arkema, Gregory Verutes, Joanna R Bernhardt, Chantalle Clarke, Samir Rosado, Maritza Canto, Spencer A Wood, Mary Ruckelshaus, Amy Rosenthal, Melanie McField, Joann de Zegher   +10 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Gender Analysis of Stress and Smoking Behavior: A Survey of Young Adults in Japan

Social Sciences
The global tobacco epidemic, claiming over 8 million lives annually, constitutes a formidable public health threat. Fatalities arise from both direct tobacco use and exposure to second-hand smoke.
Ayuka Yokoyama, Yuka Iwata, Nanami Oe, Etsuko Tadaka   +3 more
doaj   +1 more source

Driver-pressure-impact and response-recovery chains in European rivers: observed and predicted effects on BQEs [PDF]

, 2011
The report presented in the following is part of the outcome of WISER’s river Workpackage WP5.1 and as such part of the module on aquatic ecosystem management and restoration. The ultimate goal of WP5.1 is to provide guidance on best practice restoration
Dahm, V., Feld, C.K., Keizer-Vlek, H.E., Logez, M., Lorenz, A., Marzin, A., Michels, H.C.U., Verdonschot, P.F.M.   +7 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source