Results 111 to 120 of about 13,470,362 (342)

High-Throughput Photonic Time-Stretch Optical Coherence Tomography with Data Compression

IEEE Photonics Journal, 2017
Photonic time stretch enables real-time high-throughput optical coherence tomography (OCT), but with massive data volume being a real challenge.
Chaitanya K. Mididoddi, Fangliang Bai, Guoqing Wang, Jinchao Liu, Stuart Gibson, Chao Wang   +5 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The delay-time distribution of type-Ia supernovae from Sloan II

, 2012
We derive the delay-time distribution (DTD) of type-Ia supernovae (SNe Ia) using a sample of 132 SNe Ia, discovered by the Sloan Digital Sky Survey II (SDSS2) among 66,000 galaxies with spectral-based star-formation histories (SFHs).
Adelman-McCarthy, Badenes, Badenes, Bell, Bell, Blanton, Bloom, Brandt, Brinchmann, Brown, Cappellari, Cash, Chomiuk, Dan Maoz, Di Stefano, Dilday, Dilday, Filippo Mannucci, Frieman, Gallazzi, Graur, Guillochon, Guy, Hamuy, Han, Harris, Harris, Hicken, Horesh, Howell, Iben, Ilkov, Jha, Justham, Kasen, Kashi, Kozai, Leaman, Li, Li, Li, Mannucci, Mannucci, Mannucci, Maoz, Maoz, Maoz, Maoz, Maoz, Maoz, Maraston, Meng, Mennekens, Neill, Nelemans, Nomoto, Nomoto, Nugent, Pakmor, Pakmor, Patat, Press, Rest, Ruiter, Sako, Sako, Salpeter, Sand, Schaefer, Sharon, Shen, Simon, Sternberg, Sullivan, Thompson, Timothy D. Brandt, Tojeiro, Tojeiro, Totani, Treu, van Kerkwijk, Wang, Webbink, Whelan, York, Yungelson   +85 more
core   +1 more source

An inventory of mammals, birds and reptiles along a section of the river and banks of upper Ganges, India

Journal of Threatened Taxa, 2012
A study was conducted to assess faunal diversity along a 165-km stretch of the upper Ganges River between Bijnor and Narora cities, Uttar Pradesh, from January to June 2007.
T. Bashir, S.K. Behera, A. Khan, P. Gautam   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Effects of Mechanical Stretch on Collagen and Cross-Linking in Engineered Blood Vessels

Cell Transplantation, 2009
It has been shown that mechanical stimulation affects the physical properties of multiple types of engineered tissues. However, the optimum regimen for applying cyclic radial stretch to engineered arteries is not well understood.
Amy Solan, Shannon L. M. Dahl, Laura E. Niklason M.D., Ph.D.   +2 more
doaj   +1 more source

Cardiac myosin binding protein-C phosphorylation modulates myofilament length-dependent activation

Frontiers in Physiology, 2016
Cardiac myosin binding protein-C (cMyBP-C) phosphorylation is an important regulator of contractile function, however, its contributions to length-dependent (SL) changes in cross-bridge (XB) kinetics is unknown.
Ranganath eMamidi, Kenneth eGresham, Sujeet eVerma, Julian eStelzer   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source