Results 121 to 130 of about 13,470,362 (342)

Extinction of Cylindrical Diffusion Flame

Journal of Thermal Science and Technology, 2011
An experimental study was performed on the behavior and extinction characteristics of the cylindrical diffusion flame affected by both factors of stretch and curvature.
Yosuke SUENAGA, Michio KITANO, Hideki YANAOKA   +2 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Analysis of Alterations in Morphologic Characteristics of Mesenchymal Stem Cells by Mechanical Stimulation during Differentiation into Smooth Muscle Cells [PDF]

Cell Journal, 2010
Objective: Mesenchymal stem cells (MSCs) can be expanded and differentiated intomany mature cell types including smooth muscle cells (SMCs). In addition to growth factor,cyclic stretch contributes to differentiation of stem cells.
Mohammad Ali Shokrgozar, Esmaeil Jafar Gholi Rangraz, Mohammad Tafazzoli-Shadpour, Naser Amirizadeh, Nooshin Haghighipour, Samane Ghazanfari   +5 more
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Intrafusal cross‐bridge dynamics shape history‐dependent muscle spindle responses to stretch

Experimental Physiology
Computational models can be critical to linking complex properties of muscle spindle organs to the sensory information that they encode during behaviours such as postural sway and locomotion where few muscle spindle recordings exist.
Surabhi N. Simha, Lena H. Ting
doaj   +1 more source

Universal linear motor driven Leg Press Dynamometer and concept of Serial Stretch Loading

European Journal of Translational Myology, 2015
Paper deals with backgrounds and principles of universal linear motor driven leg press dynamometer and concept of serial stretch loading. The device is based on two computer controlled linear motors mounted to the horizontal rails. As the motors can keep
Dušan Hamar
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Evolution in the Volumetric Type Ia Supernova Rate from the Supernova Legacy Survey [PDF]

, 2012
We present a measurement of the volumetric Type Ia supernova (SN Ia) rate (SNR_Ia) as a function of redshift for the first four years of data from the Canada-France-Hawaii Telescope Supernova Legacy Survey (SNLS).
Neill, J. D., Perrett, K.
core  

An Experimental Investigation of Hyperbolic Routing with a Smart Forwarding Plane in NDN

, 2016
Routing in NDN networks must scale in terms of forwarding table size and routing protocol overhead. Hyperbolic routing (HR) presents a potential solution to address the routing scalability problem, because it does not use traditional forwarding tables or
Aldecoa, Rodrigo, Gawande, Ashlesh, Krioukov, Dmitri, Lehman, Vince, Wang, Lan, Zhang, Beichuan, Zhang, Lixia   +6 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source