Results 71 to 80 of about 13,470,362 (342)

Stretch Induced Hyperexcitability of Mice Callosal Pathway

Frontiers in Cellular Neuroscience, 2015
Memory and learning are thought to result from changes in synaptic strength. Previous studies on synaptic physiology in brain slices have traditionally been focused on biochemical processes.
Anthony eFan, Kevin Ambrose Stebbings, Daniel Adolfo Llano, Daniel Adolfo Llano, Daniel Adolfo Llano, Daniel Adolfo Llano, Taher eSaif   +6 more
doaj   +1 more source

Force enhancement and relaxation rates after stretch of activated muscle fibres [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2005
The residual force enhancement following muscle stretch might be associated with an increase in the proportion of attached cross-bridges, as supported by stiffness measurements. In this case, it could be caused by an increase in the attachment or a decrease in the detachment rate of cross-bridges, or a combination of the two.
Dilson E, Rassier, Walter, Herzog
openaire   +2 more sources

Force encoding in muscle spindles during stretch of passive muscle

PLoS Comput. Biol., 2017
Muscle spindle proprioceptive receptors play a primary role in encoding the effects of external mechanical perturbations to the body. During externally-imposed stretches of passive, i.e.
Kyle P. Blum, B. L. d'Incamps, D. Zytnicki, L. Ting   +3 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Enhancement of PC12 axonal extension via hybrid electromagnetic and mechanical stimulation

Journal of Biomechanical Science and Engineering, 2018
In this study, a hybrid electromagnetic and mechanical stimulation system that can apply an alternative current magnetic field (ACMF) and tensile strain fields on PC12 cells was developed to enhance nerve axonal extension. For the ACMF stimulation system,
Eiji NAKAMACHI, Kazuya MATSUMOTO, Ryota SAKIYAMA, Koji YAMAMOTO, Yusuke MORITA   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Coherent laser source for high frame-rate optical time-stretch microscopy at 1.0 μm [PDF]

, 2014
We demonstrate a coherent picosecond pulsed fiber laser for the high frame-rate optical time-stretch microscopy at 1.0 μm. The spectrum of a picosecond pulsed laser is commonly broadened before the time-stretch imaging, which however will degrade its ...
Lau, AKS, Tsia, KKM, Wei, X, Wong, KKY, Wong, TTW, Zhang, C   +5 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source