Results 121 to 130 of about 147,438 (217)

Cross‐Platform Concordance Between Metagenomic and Targeted DNA Sequencing for Diagnosing Polymicrobial Infections in an Immunosuppressed Patient: A Case Report

Medicine Advances, EarlyView.
An immunosuppressed 40‐year‐old man developed rapidly progressive polymicrobial pneumonia caused by Pneumocystis jirovecii and carbapenem‐resistant Klebsiella pneumoniae. Three metagenomic next‐generation sequencing (mNGS) and targeted next‐generation sequencing (tNGS) workflows with different assay designs and technical parameters consistently ...
Mengxia Wang, Jielun Wen, Liyue Sun
wiley   +1 more source

Therapeutic Impact of GLP‐1 Receptor Agonists on Parkinson's Disease: A Scoping Review

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT No disease‐modifying treatment exists for Parkinson's disease (PD). Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have gained attention as promising candidates for neuroprotection, given documented expression of GLP‐1 receptors within the central nervous system and the contribution of brain insulin resistance to dopaminergic ...
João Pedro Henriques, João Pedro Stringhetta Rahal, Rafael da Cunha Gomes Ribeiro, Enzo Bogucheski Ribeiro Machado, Carlos Antonio Negrato   +4 more
wiley   +1 more source

Exploring Cognitive and Affective Outcomes Following Bilateral 6-Hydroxydopamine Lesions of the Substance Nigra or Striatum in Rats. [PDF]

J Neurosci Res
de Mattos BA, Del Bel E, Milani H, de Oliveira RMW, Bonato JM.   +4 more
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Aberrant salience is selectively associated with ventral midbrain connectivity to the dorsal but not ventral striatum. [PDF]

Schizophrenia (Heidelb)
Li Y, Oishi N, Dai Q, Nakagami Y, Yao L, Kawashima T, Yoshihara Y, Kubota M, Nakamura Y, Koike S, Murai T, Miyata J.   +11 more
europepmc   +1 more source

Revealing the dark biodiversity around us through a national school‐based citizen science project

People and Nature, EarlyView.
Abstract School‐based citizen science holds great potential for expanding biodiversity knowledge while engaging young people in authentic scientific practices. This is particularly important for revealing ‘dark biodiversity’, defined as the vast yet often overlooked biodiversity that remains hidden due to its small size or cryptic nature, including ...
Juan Ignacio Ramirez, Marie Rathcke Lillemark, Lene Christensen, Majken Mosegaard Svendsen, Frederik Leerhøi, Piotr Gąsiorek, Martin Vinther Sørensen, Anders P. Tøttrup   +7 more
wiley   +1 more source

Atopic dermatitis and attention‐deficit/hyperactivity disorder comorbidity in children and adolescents: Epidemiology, mechanisms, and clinical management

Pediatric Investigation, EarlyView.
This review synthesizes epidemiological evidence linking atopic dermatitis to attention‐deficit/hyperactivity disorder in children, proposes an “inflammation‐itch‐neurobehavioral axis” integrating sleep disruption, neuroendocrine dysregulation, and emerging neuro‐immune circuits, and outlines multidisciplinary management strategies targeting both skin ...
Qingyang Zhao, Yuan Liang, Ying Liu, Chunping Shen, Mutong Zhao, Jing Tian, Lei Jiao, Jing Sun, Ying Gu, Qiong Wu, Shan Wang, Lin Ma   +11 more
wiley   +1 more source

Comparable Acute Antidepressant-like Effects of Two Subanesthetic Ketamine Doses Are Associated with Divergent Region-Specific Molecular Responses After Adolescent Chronic Stress. [PDF]

Int J Mol Sci
Zivanovic A, Lukic I, Glavonic E, Brkic Z, Mitic M, Ivkovic S, Adzic M.   +6 more
europepmc   +1 more source

Brassinin Inhibits Cell Survival and Autophagy via Modulation of ROS Production and the AMPKα‐beclin1 Signaling Pathway in Gliomas

Phytotherapy Research, EarlyView.
Brassinin, a phytoalexin derived primarily from Chinese cabbage, exhibits potent anticancer activity against glioblastoma (GBM). Mechanistically, brassinin treatment elevates intracellular ROS levels in GBM cells, triggering two parallel outcomes: (i) direct induction of apoptosis, and (ii) suppression of cytoprotective autophagy through downregulation
Sunil Rauniyar, Yuhui Wang, Qiaoshan Zhang, Shicheng Zhang, Jiale Yin, Tong Zhang, Shangfeng Gao, Rutong Yu   +7 more
wiley   +1 more source

Ginsenoside Rh1 Attenuates Alzheimer's Disease‐Like Deficits by Modulating Oxidative Stress and Mitochondrial Dysfunction via SIRT1‐Related Signaling

Phytotherapy Research, EarlyView.
Rh1 attenuates oxidative stress and mitochondrial dysfunction through SIRT1‐related signaling. ABSTRACT Alzheimer's disease (AD) remains a progressive neurodegenerative disorder with limited therapeutic options. Ginsenoside Rh1 has been reported to possess neuroprotective properties, yet its specific role and underlying mechanisms in AD are not fully ...
Shi‐Lu Li, Tao Lin, Wan‐chen Zou, Ya‐jun Wang, Jing‐tian Zhang, Zi Wang, Hong‐yuan Li, Long Chen, Li‐chun Zhao, Shen Ren, Wei Li   +10 more
wiley   +1 more source