Results 111 to 120 of about 147,438 (217)

Apathy in Lewy Body Disorders: A Position Paper

Movement Disorders, EarlyView.
Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky, Lidia Bojtos, Milica G. Kramberger, Elisa Mantovani, Iulia Murasan, Jose‐Alberto Palma, Karolina Poplawska‐Domaszewicz, Anna Sauerbier, Kallol Ray Chaudhuri, Per Odin, Daniel Weintraub, Anette Schrag, Cristian Falup‐Pecorariu   +12 more
wiley   +1 more source

Loss of C3 and CD14 reduces region-specific neuroinflammation in a murine polytrauma model. [PDF]

Inflamm Res
Olde Heuvel F, Pagliarini M, Sun F, Lupu L, Zhao Z, Cui L, Zhang J, Halbgebauer R, Mannes M, Boeckers TM, Knöll B, Lien E, Mollnes TE, Huber-Lang M, Roselli F.   +14 more
europepmc   +1 more source

Spatiotemporal Tau Accumulation and its Clinical Impact on Progressive Supranuclear Palsy: Longitudinal Florzolotau (18F) Positron Emission Tomography

Movement Disorders, EarlyView.
Abstract Background Florzolotau (18F) positron emission tomography (florzolotau PET) enables high‐contrast in vivo detection of four‐repeat tau pathology in progressive supranuclear palsy (PSP), but whether longitudinal tau imaging reflects disease progression remains unclear.
Yoshikazu Chishiki, Kenji Tagai, Yuko Kataoka, Ryoji Goto, Kenta Osawa, Asaka Oyama, Hideki Matsumoto, Masanori Ichihashi, Yuki Momota, Tetsuji Kamada, Chie Seki, Kiwamu Matsuoka, Kosei Hirata, Shin Kurose, Sho Moriguchi, Yuki Komatsu, Hideo Kato, Yasuharu Yamamoto, Yoshikazu Nakano, Shigeki Hirano, Hitoshi Shinotoh, Hitoshi Shimada, Tokahiko Tokuda, Kazunori Kawamura, Ming‐Rong Zhang, Keisuke Takahata, Makoto Higuchi, Hironobu Endo   +27 more
wiley   +1 more source

Regional Expression Profiles of Artemin Protein and GFRα3 mRNA During Postnatal Brain Development in Rats. [PDF]

Biology (Basel)
Demirtaş D, Gülcen B, Çalışkan H.
europepmc   +1 more source

Striatal Dopaminergic Reserve Shapes the Longitudinal Impact of Peripheral Immune Activation on Motor Progression in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Peripheral immune dysregulation has been implicated in Parkinson's disease (PD) progression, but whether motor deterioration reflects accelerated nigrostriatal degeneration or residual dopaminergic reserve remains unclear. Objectives To examine whether baseline and time‐varying neutrophil‐to‐lymphocyte ratio (NLR) relate to motor ...
Osman Kahveci, Ulaş Ay, Tamer Demiralp
wiley   +1 more source

Sex-dependent mild cardiac dysfunction and neurometabolic abnormalities in a model of Huntington's disease. [PDF]

Dis Model Mech
Hynes KLR, O'Brien TM, Hanrahan J, Neita R, Burry TN, Hayden MR, Parsons MP, Southwell AL, Cahill LS.   +8 more
europepmc   +1 more source

Neurofilament Light Chain and Mutant Huntingtin Across Huntington's Disease Integrated Staging System Stages in Huntington Disease: A Cross‐Sectional Multimodal Analysis

Movement Disorders, EarlyView.
Abstract Background The Huntington's Disease Integrated Staging System (HD‐ISS) provides a framework for staging HD but does not incorporate fluid biomarkers. Objective The aim of this study was to examine neurofilament light chain (NfL) and mutant huntingtin (mHTT) and total tau across HD‐ISS stages and their associations with genetic burden ...
Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Arnau Puig Davi, Rocío Pérez González, Jordi Pegueroles, Andrea Horta‐Barba, Anna Vázquez Oliver, Elisa Rivas Asensio, Daniel Alcolea, Juan Fortea, Marina Guasch‐Jiménez, Tomas Xuclà Ferrarons, Frederic Sampedro Santaló, Lidia Bojtos, Óscar López‐Lombardía, Ignacio Aracil‐Bolaños, Berta Pascual‐Sedano, Carla Franch Martí, Laura Pérez Carasol, Margarita Rubio Romera, Yi Ji, Alexandre Gironell, Antonia Campolongo, Raul Martínez‐Fernández, Alberto Lleó, Javier Pagonabarraga, Saul Martínez‐Horta, Jaime Kulisevsky, BCN‐HD Working Group;, HDClarity investigators, Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Saül Martínez‐Horta, Arnau Puig‐Davi, Carla Franch, Paula Arranz‐Horno, Oscar López‐Lombardía, Lidia Bojtos, Antonia Campolongo, Javier Pagonabarraga, Jaime Kulisevsky, Asunción Ávila, Nuria Caballol, Alejandro Peral, Jesús Ruíz‐Idiago, Misericordia Floriach, Matilde Calopa, Helena Bejr Kasem, Clara Marzal Espí, Esteban Muñoz, Celia Painous, Irene Navalpotro, Victor Puente, Victoria González, Pau Pastor, Dolores Vilas, Iñigo Ruiz Barrio, Lourdes Ispierto, Eliot Gómez‐López, Claustre Pons, Gracia Pons, Maria Teresa Buongiorno, Anna Mas, Maria Pilar Gil, Jordi Casanovas, Edward Wild, Tiago Mestre, Mark Guttman, Philippe Rizek, Blair Leavitt, Carsten Saft, Bjorn Falkenburger, Juergen Winkler, Ralf Reilmann, Jan Lewerenz, Alzbeta Mühlbäck, Jesús Pérez‐Pérez, Tamara Fernandez Valle, José Luis López‐Sendón Moreno, Christophe Verny, Cyril Goizet, Caterina Mariotti, Ferdinando Squitieri, Tim Anderson, Richard Roxburgh, Grzegorz Witkowski, Leonor Correia Guedes, Hugh Rickards, Elizabeth Coulthard, Roger Barker, Anne Rosser, Tim Harrower, Robert Thompson, James Herron, Jeremy Cosgrove, Rhys Davies, Nayana Lahiri, Richard Armstrong, Daniel Lashley, Jee Bang, Erin Furr‐Stimming, Jessica Tate, Meagen Salinas, Karen Anderson, Amy Brown   +104 more
wiley   +1 more source

Optimizing Genetic Analyses for Movement Disorders: A Unified Panel Approach and Targeted Reanalysis of 4,046 Clinical Exomes

Movement Disorders, EarlyView.
Abstract Background Molecular testing for genetic movement disorders (MDs) increasingly relies on exome‐ or genome‐based virtual gene panels. In the absence of consensus guidelines, MD panel design remains heterogeneous across laboratories, with international variation in panel configuration and gene content.
Teodora Barbarii, Sanne P. Smeekens, Maartje Pennings, Galuh Astuti, Lisenka E.L.M. Vissers, Helger G. Yntema, Christian Gilissen, Bart van de Warrenburg, Erik‐Jan Kamsteeg   +8 more
wiley   +1 more source

Editorial: The role of cellular subtypes in striatal activity. [PDF]

Front Cell Neurosci
Fino E, Assous M, Fuccillo MV.
europepmc   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source