Results 161 to 170 of about 192,251 (301)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Differential metabolic and cellular brain regional susceptibility in adult rats with chronic liver disease. [PDF]

Metab Brain Dis
Simicic D, Pierzchala K, Braissant O, Sessa D, McLin V, Cudalbu C.   +5 more
europepmc   +1 more source

Decoding neuronal vulnerability: Multidimensional analysis of D1R- and D2R- medium-sized spiny neurons in Huntington's disease. [PDF]

Brain Pathol
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Bergonzoni G, Pellegrini M, Savino A, Lazioli M, Geurs S, Graziani L, Ferrarini D, Tusi SK, Oliver E, Geurts J, Vinciguerra S, Tebaldi M, Tripathi T, Pesce I, Poli V, Romanel A, Moratalla R, Voet T, Morandell J, Sanges R, Wheeler VC, Dassi E, Biagioli M.   +22 more
europepmc   +2 more sources

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Reward processing in children with affective dysregulation

JCPP Advances, EarlyView.
Abstract Background Affective dysregulation (AD) in children is characterized by irritability, anger, and frequent intense temper outbursts. Considerable evidence implies altered processing of frustration about missed rewards, but few studies investigated the preceding and thus potentially predictive reward anticipation and initial delivery processing ...
Pascal‐M. Aggensteiner, Francisca Giller, Nathalie Holz, Anna Kaiser, Christine Igel, Sarah Hohmann, Manfred Döpfner, Veit Roessner, Christian Beste, Tobias Banaschewski, Daniel Brandeis, on behalf ofthe ADOPT Consortium   +11 more
wiley   +1 more source

Distinct electrophysiology and dopaminergic modulation of medium spiny neurons across divisions of the tail striatum and the dorsolateral striatum. [PDF]

Exp Physiol
Riley B, Hallum LE, Vlajkovic SM, Montgomery JM, Freestone PS.   +4 more
europepmc   +1 more source

Identifiable regional and neural network abnormalities in early childhood anxiety

JCPP Advances, EarlyView.
Abstract Background Although the neural underpinnings of anxiety have been investigated, most research has been confined to adolescence and adulthood, with less of a focus on the early childhood period. Little is known about the role of anticipatory fear processing early childhood, which is a sensitive period for anxiety development.
Khalil I. Thompson, Yiwen Zhang, Denny Schaedig, Anna Bankston, Anoushka Parnerkar, Shrinidhi Jeyaram, Nadine Melhem, Susan B. Perlman   +7 more
wiley   +1 more source

δ2-Protocadherins organize parallel indirect basal ganglia circuits. [PDF]

Sci Adv
Hoshina N, Boeckers JM, Johnson-Venkatesh EM, Hoshina M, Matsumoto K, Das A, Rally VR, Sant J, Terauchi A, Kinoshita S, Inoue T, Umemori H.   +11 more
europepmc   +1 more source