Results 181 to 190 of about 192,251 (301)

Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Chiara Meneghini, Luca Gallo, Arianna Sala, Enza Maria Valente, Micol Avenali, Silvia Paola Caminiti   +5 more
wiley   +1 more source

Integrated Liquid Chromatography-Tandem Mass Spectrometry and Headspace Solid-Phase Microextraction With Gas Chromatography-Mass Spectrometry-based Profiling Reveals Developmental Metabolic Dynamics of Ligusticum striatum DC. [PDF]

J Sep Sci
Tung NKT, Nam NH, Nhiem NX, Dat NT, Kwon SW, Kang JS, Kim HM.   +6 more
europepmc   +1 more source

Apathy in Parkinson's Disease: Distinguishing Overlapping Symptoms Via Network Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Anxiety, fatigue, and excessive daytime sleepiness (EDS) frequently co‐occur in Parkinson's disease (PD) and can influence the clinical determination of apathy. Objective To distinguish patient‐reported apathy from other non‐motor symptoms.
Joseph Seemiller, Abhimanyu Mahajan, Christopher B. Morrow, Joseph F. McGuire, Dawn Bowers, Kelly A. Mills, Gregory M. Pontone   +6 more
wiley   +1 more source

Mild Subcortical Stroke Induces Widespread Chronic Reactive Astrogliosis That Is Largely Unaffected by Microglia and Age. [PDF]

ASN Neuro
Stackhouse TL, Marxmiller BD, Sullivan SJ, McConnell HL, Knittel LM, De La Torre R, Houser A, Ismail O, Zhang W, Woltjer RL, Mishra A.   +10 more
europepmc   +1 more source

Acute and Chronic Local Field Potential Recordings in Dystonia—A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Dystonia is a hyperkinetic movement disorder increasingly conceptualized as a disorder of distributed network dysfunction involving the basal ganglia, cortex and cerebellum. Local field potentials (LFPs) recorded from deep brain stimulation (DBS) electrodes provide a unique opportunity to characterize the electrophysiological signatures ...
Jack Horan, Eoghan Donlon, Aoibheann Gill, Rosalyn Moran, Conor Fearon, Richard A. Walsh, Catherine Moran   +6 more
wiley   +1 more source

Machine Learning Prediction of Hoehn and Yahr Scores at 5‐Years Post‐123I‐Ioflupane SPECT Imaging in a Real‐World Parkinson's Disease Dataset

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) progression is highly heterogeneous, complicating clinical management and prognostication. While machine learning models have been developed using research datasets such as Parkinson's Precision Medicine Initiative (PPMI) and Parkinson's Disease Biomarkers Program (PDBP), their clinical translatability is ...
Xuehua Ye, Mette Niemann Johansen, Balazs Laczi, Mads Peter Horndrup, Michael Zaucha Sørensen, Rasmus Vestergård Madsen, Jan Wolber, Markus Lonsdale, Annemette Lokkegaard, Renee Miller   +9 more
wiley   +1 more source

Shaping of developmental gradients through selection on multiple loci in <i>Antirrhinum</i>. [PDF]

Sci Adv
Bradley D, Boell L, Richardson D, Copsey L, Whibley A, Xu T, Zhang Y, Xue Y, Field D, Coen E.   +9 more
europepmc   +1 more source

Exercise and Motor Complications in Parkinson's Disease: A Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Levodopa remains the most effective pharmacological treatment for Parkinson's disease (PD), but long‐term use commonly leads to motor complications such as levodopa‐induced dyskinesia (LID) and motor fluctuations, significantly contributing to disability. Exercise is well‐established for improving motor and non‐motor symptoms in PD;
Priscila Nóbrega‐Sousa, Lucas H.C.C. Santos, Jane Alty, Peter Humburg, Kim Delbaere, Paulo H.S. Pelicioni   +5 more
wiley   +1 more source

Norepinephrine and dopamine sensor crosstalk depends on local innervation density. [PDF]

Nat Neurosci
López RC, Noble N, Özçete ÖD, Silenzi L, Cai X, Handy GE, Andersen JW, Patriarchi T, Li Y, Kaeser PS.   +9 more
europepmc   +1 more source

Transcranial Pulse Stimulation Enhances Dexterity in Parkinson's Disease: A Randomized Sham‐Controlled Trial

Movement Disorders, EarlyView.
Abstract Background Ultrasound‐based neuromodulation, capable of reaching deep brain areas with high precision, represents cutting‐edge technology in non‐invasive brain stimulation and is investigated as a novel treatment for neurological and psychiatric disorders, including Parkinson's disease (PD).
Eva Matt, Nina Plischek, Michael Mitterwallner, Sonja Radjenovic, Alexandra Weber, Alina Domitner, Gregor Dörl, Anna Zettl, Sarah Osou, Anna Leitgeb, Agnes Santer, Viktoria Winkler, Julia Mandelburger, Heidemarie Zach, Roland Beisteiner   +14 more
wiley   +1 more source