Results 311 to 320 of about 325,395 (379)

Dopamine D3 receptor blockade accelerates the extinction of opioid withdrawal‐induced drug‐seeking behaviours and alters microglia in dopaminoceptive nuclei

British Journal of Pharmacology, EarlyView.
Background and Purpose Among all drugs of abuse, opioids cause most of the deaths and treatment seeking. Despite abundant research in multifaceted therapeutic strategies, a high rate of relapse still characterises this condition. Dopamine D3 receptor antagonists combined with cue‐exposure therapies have been proposed to ameliorate the abused drugs ...
Aurelio Franco‐García, Victoria Gómez‐Murcia, M. Victoria Milanés, Cristina Núñez   +3 more
wiley   +1 more source

A GLP‐1R/Y1 receptor/Y2 receptor triple agonist decreases fentanyl‐evoked dopamine release in the nucleus accumbens and attenuates fentanyl taking and seeking in rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Emerging literature indicates that simultaneously targeting glucagon‐like peptide‐1 receptors (GLP‐1Rs) and neuropeptide Y receptors (Y1/Y2) may represent a new pharmacotherapeutic approach to treating opioid use disorder (OUD).
Antonia Caffrey, Enzo Lavecchia, Kylie S. Chichura, Matthew R. Hayes, Robert P. Doyle, Heath D. Schmidt   +5 more
wiley   +1 more source

Exercise promotes the functional integration of human stem cell-derived neural grafts in a rodent model of Parkinson's disease. [PDF]

Stem Cell Reports
Moriarty N, Fraser TD, Hunt CPJ, Eleftheriou G, Kauhausen JA, Thompson LH, Parish CL.   +6 more
europepmc   +1 more source

Effect of Etomidate on In Vivo Ischemia-Induced Dopamine Release in the Corpus Striatum of the Rat

, 1994
Robert Koorn, T. Brannan, J. Martínez-Tica, Jesse Weinberger, David L. Reich   +4 more
openalex   +1 more source

PIK3C2A‐Related Clinical Phenotype and Cellular Charaterization Linked to Functional SHH Primary Cilia Defect

Clinical Genetics, EarlyView.
Trio exome sequencing allowed the identification of two novel compound heterozygous variants in PIK3C2A, defining the fifth family presenting a PIK3C2A‐related syndrome characterized by pulverulent cataracts and deafness. Functional testing revealed impaired PI metabolism and primary dysfunction phenotype.
Adella Karam, Clarisse Delvallée, Bénédicte Gérard, Elodie Javey, Pascal Kessler, Valérie Pelletier, Jean‐Baptiste Lamouche, Nicolas Le May, Jean Muller, Hélène Dollfus   +9 more
wiley   +1 more source

Metagenomic next-generation sequencing for the diagnosis of Corynebacterium striatum meningitis: case report and literature review. [PDF]

BMC Neurol
Zhao X, Liu X, Wang Z, Wei S, Wu Z.
europepmc   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He   +4 more
wiley   +1 more source

Striatal function scrutinized through the PAN-TAN-FSI triumvirate. [PDF]

Front Cell Neurosci
Apicella P, Martel AC, Marche K.
europepmc   +1 more source

Skin microbiome analysis of a junctional epidermolysis bullosa patient treated with genetically modified stem cells

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objective Junctional epidermolysis bullosa (JEB) is a subtype of epidermolysis bullosa caused by mutations in the LAMB3 gene. We treated a patient with JEB using genetically corrected autologous epidermal cultures retrovirally transduced with the functional LAMB3 gene sequence.
Alexander Dermietzel, Burcu Tosun, Mathilde Nguyen, Kai Wessel, Luise Rauer, Avidan U. Neumann, Tobias Hirsch, CK‐CARE study group, Claudia Traidl‐Hoffmann, Matthias Reiger, Claudia Hülpüsch, Maximilian Kueckelhaus   +11 more
wiley   +1 more source

Neuroanatomical Mapping of Gerbil Corticostriatal and Thalamostriatal Projections Reveals the Parafascicular Nucleus as a Relay for Vestibular Information to the Entire Striatum. [PDF]

eNeuro
Smith JB, Hong SS, Murphy DJ, Dangcil E, Nacipucha J, Tucker A, Carayannopoulos NL, Beshy M, Chandrasekar S, Peci E, Kiel MY, Wackym PA, Yao JD, Mowery TM.   +13 more
europepmc   +1 more source