Results 81 to 90 of about 147,438 (217)

Scn1a‐mediated developmental regulation of prefrontal cortex plasticity and cognition

Epilepsia, EarlyView.
Abstract Objective The voltage‐gated sodium channel Nav1.1, encoded by Scn1a, is essential for γ‐aminobutyric acid (GABA)ergic function, and its alteration is associated with neurological disorders such as Dravet syndrome and Alzheimer's disease. We previously demonstrated that local Nav1.1 dysfunction in the medial prefrontal cortex (mPFC) during ...
Maurizio S. Riga, Mercedes Pérez‐Fernández, Yuniesky Andrade‐Talavera, Benito Domínguez‐Velasco, Antonio Rodríguez‐Moreno, Manuel Álvarez‐Dolado   +5 more
wiley   +1 more source

Limited sex‐specific structural alterations across common epilepsies: A worldwide ENIGMA study

Epilepsia, EarlyView.
Abstract Objective Epilepsy is characterized by widespread cortical and subcortical structural alterations beyond the epileptic zone. Importantly, the clinical manifestation of epilepsy, including seizure types, psychiatric comorbidities, and treatment responses, has been shown to differ between sexes. However, sex differences in structural alterations
Huantao Wen, Bin Wan, Taha Gholipour, Ke Xie, Judy Chen, Bianca Serio, Meike D. Hettwer, Marina K. M. Alvim, Donatello Arienzo, Rafael Batista João, Tobias Bauer, Andrea Bernasconi, Neda Bernasconi, Paolo Bonanni, Maria Eugenia Caligiuri, Fernando Cendes, Raphaël Christin, Luis Concha, Arielle Dascal, Edward Davoodi Boyd, Orrin Devinsky, Niels K. N. Focke, Francesco Fortunato, Marian Galovic, Antonio Gambardella, Renzo Guerrini, Sean N. Hatton, Mirana Iliza, Sara Inati, Victoria Ives‐Deliperi, Robert‐Paul Juster, Jonathan K. Kleen, Mohamad Z. Koubeissi, Angelo Labate, Sara Larivière, Meng Law, Matteo Lenge, Stefano Meletti, Patrick B. Moloney, Marlo Naish, Alexander Ngo, Terence J. O'Brien, Raluca Pana, Sofia Panzeri, Heath Pardoe, Erik H. U. Rauf, Antonella Riva, Raúl Rodríguez‐Cruces, Jessica Royer, Theodor Rüber, Ella Sahlas, Lucas Scárdua‐Silva, Kai Michael Schubert, Leigh N. Sepeta, Mariasavina Severino, Benjamin Sinclair, Hamid Soltanian‐Zadeh, Travis Stoub, Pasquale Striano, Sophia I. Thomopoulos, Nina V. Valientes, Anna Elisabetta Vaudano, Lucy Vivash, Clarissa L. Yasuda, Paul M. Thompson, Sanjay M. Sisodiya, Carrie R. McDonald, Boris C. Bernhardt, Sofie L. Valk   +68 more
wiley   +1 more source

Transcriptome analyses suggest minimal effects of Shank3 dosage on directional gene expression changes in the mouse striatum

Animal Cells and Systems, 2019
Both deletions and duplications of the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene, encoding excitatory postsynaptic scaffolds, are causally associated with various brain disorders, suggesting that proper Shank3 dosage is critical for normal ...
Yeunkum Lee, Hyojin Kang, Chunmei Jin, Yinhua Zhang, Yoonhee Kim, Kihoon Han   +5 more
doaj   +1 more source

Adeno‐associated virus‐mediated restoration of NaV1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of NaV1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden ...
Martina Mainardi, Simone Brusco, Serena Gea Giannelli, Vania Broccoli, Gaia Colasante   +4 more
wiley   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Research progress on the use of the optical coherence tomography system for the diagnosis and treatment of central nervous system tumors

Ibrain, Volume 11, Issue 1, Page 3-18, Spring 2025.
With the advantages of high‐resolution imaging, efficient image acquisition, intraoperative real‐time detection, and radiation‐free and noninvasive characteristics, optical coherence tomography (OCT) provides accurate diagnosis and effective intraoperative guidance for the minimally invasive diagnosis and treatment of central nervous system (CNS ...
Jiuhong Li, Ziba Ayi, Gonggong Lu, Haibo Rao, Feilong Yang, Jing Li, Jiachen Sun, Junlin Lu, Xulin Hu, Si Zhang, Xuhui Hui   +10 more
wiley   +1 more source

Modification of Monoaminergic Activity by MAO Inhibitors Influences Methamphetamine Actions

Drug Target Insights, 2006
Methamphetamine (METH) abuse is a serious health and social problem worldwide. At present, however, there are no effective medications for the treatment of METH abuse.
Junichi Kitanaka, Nobue Kitanaka, Motohiko Takemura   +2 more
doaj  

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source