Results 81 to 90 of about 178,790 (312)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Changes in striatal dopamine transporters in bipolar disorder and valproate treatment

European Psychiatry, 2021
BackgroundPrevious studies suggested that a disturbance of the dopamine system underlies the pathophysiology of bipolar disorder (BD). In addition, the therapeutic action of medications for treating BD, such as valproate (VPA), might modulate dopamine ...
Yuan-Shuo Hsueh, Chih-Ying Lin, Nan-Tsing Chiu, Yen Kuang Yang, Po See Chen, Hui Hua Chang   +5 more
doaj   +1 more source

Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese

, 2016
Manganese (Mn) is an essential trace element required for a range of physiological processes, but Mn can also be neurotoxic especially during development.
Eyng, Helena, Venske, De´bora K. R., Lopes, Mark W., Dunkley, Peter R., Costa, Ana Paula, Farina, Marcelo, Dickson, Phillip W., Peres, Tanara V., Aschner, Michael, Leal, Rodrigo B., Colle, Dirleise, Ong, Lin K., Gonçalves, Filipe M.   +12 more
core   +1 more source

Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Advanced Functional Materials, EarlyView.
We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang, Yi Xie, Sihan Yu, Thomas Wynn, Xiangping Liu, Ju‐Chun Hsieh, Jinmo Jeong, Weilong He, Brinkley Artman, Anakaren Romero Lozano, Xi Shi, Arjun Sangani, Lief E Fenno, Samantha Santacruz, Banglin Chen, Huiliang Wang   +18 more
wiley   +1 more source

PFCTEXD - Striatum

, 2022
Distributed and interconnected representation of different task context in striatum and lateral ...
Peter Stiers
core   +1 more source

Hypoxia Disrupted Serotonin Levels in the Prefrontal Cortex and Striatum, Leading to Depression-like Behavior

Biology
Hypoxia can adversely affect multiple organ systems. This study investigated the impact of intermittent hypoxia on serotonin levels and depression-like behaviors across distinct neuroanatomical regions.
Hasan Çalışkan, Koray Hamza Cihan, Seda Koçak, Gözde Karabulut, Erhan Nalçacı   +4 more
doaj   +1 more source

Multisensory Integration in the Mouse Striatum [PDF]

Neuron, 2014
The basal ganglia are involved in sensorimotor functions and action selection, both of which require the integration of sensory information. In order to determine how such sensory inputs are integrated, we obtained whole-cell recordings in mouse dorsal striatum during presentation of tactile and visual stimuli.
Ramon Reig, Gilad Silberberg
openaire   +3 more sources

Soft Neural Interfaces for Circuit‐Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models

Advanced Healthcare Materials, EarlyView.
ABSTRACT Magnetogenetic deep brain stimulation (MG‐DBS) represents a wireless neuromodulation that has demonstrated long‐lasting behavioral benefits in Parkinson's disease models. However, the circuit‐level mechanisms underlying these therapeutic effects have remained uncharacterized due to limitations of conventional neural interfaces.
Jakyoung Lee, Yeongdo Lee, Enji Kim, Hunkyu Seo, Myoungjae Oh, Hanho Joo, Somin Lee, Jae‐Hyun Lee, Hyun Ho Jung, Minsuk Kwak, Jang‐Ung Park   +10 more
wiley   +1 more source

A neural network model combining the successor representation and actor-critic methods reveals effective biological use of the representation

Frontiers in Computational Neuroscience
In learning goal-directed behavior, state representation is important for adapting to the environment and achieving goals. A predictive state representation called successive representation (SR) has recently attracted attention as a candidate for state ...
Takayuki Tsurumi, Kenji Morita, Kenji Morita   +2 more
doaj   +1 more source

Changes in functional connectivity within the rat striatopallidal axis during global brain activation in vivo

, 2006
The functional organization of the basal ganglia (BG) is often defined according to one of two opposing schemes. The first proposes multiple, essentially independent channels of information processing.
Sharott, A, Brown, Peter, Bolam, JP, Pogosyan, A, Magill, PJ, Brown, P, Csicsvari, J   +6 more
core   +1 more source