Results 71 to 80 of about 192,251 (301)

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Hypoxia Disrupted Serotonin Levels in the Prefrontal Cortex and Striatum, Leading to Depression-like Behavior

Biology
Hypoxia can adversely affect multiple organ systems. This study investigated the impact of intermittent hypoxia on serotonin levels and depression-like behaviors across distinct neuroanatomical regions.
Hasan Çalışkan, Koray Hamza Cihan, Seda Koçak, Gözde Karabulut, Erhan Nalçacı   +4 more
doaj   +1 more source

Lateralization of dynorphin gene expression in the rat striatum

, 2008
Hemispheric lateralization is well known in the cerebral cortex, but not in subcortical structures like basal ganglia. The goal of our study was to determine whether lateralization was present in the direct and indirect striatal pathways. We studied gene
Capper-Loup, Christine, Kaelin-Lang, Alain   +1 more
core   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

A neural network model combining the successor representation and actor-critic methods reveals effective biological use of the representation

Frontiers in Computational Neuroscience
In learning goal-directed behavior, state representation is important for adapting to the environment and achieving goals. A predictive state representation called successive representation (SR) has recently attracted attention as a candidate for state ...
Takayuki Tsurumi, Kenji Morita, Kenji Morita   +2 more
doaj   +1 more source

Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

Advanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu, Cort Thompson, Thomas Deakin, Yan Xu, Colleen A. McClung, Xinyan Tracy Cui   +5 more
wiley   +1 more source

Characterization of the tyrosine-hydroxylase immunoreactive components of the basal subpallium in sharks—toward an identification of a basal subpallial complex

Frontiers in Neuroanatomy
Comparative studies on the forebrain across different model organisms are necessary to investigate the origin and degree of evolutionary conservation of this brain region and its derivatives. The catshark Scyliorhinus canicula has become a reliable model
Isabel Rodríguez-Moldes, Catalina Sueiro, Iván Carrera, Idoia Quintana-Urzainqui, Eva Candal   +4 more
doaj   +1 more source

Multisensory Integration in the Mouse Striatum [PDF]

Neuron, 2014
The basal ganglia are involved in sensorimotor functions and action selection, both of which require the integration of sensory information. In order to determine how such sensory inputs are integrated, we obtained whole-cell recordings in mouse dorsal striatum during presentation of tactile and visual stimuli.
Ramon Reig, Gilad Silberberg
openaire   +3 more sources

Role of Dorsal Striatum Histone Deacetylase 5 in Incubation of Methamphetamine Craving

, 2018
BACKGROUND: Methamphetamine (meth) seeking progressively increases after withdrawal (incubation of meth craving). We previously demonstrated an association between histone deacetylase 5 (HDAC5) gene expression in the rat dorsal striatum and incubation of
Jianjun Zhang, Bossert, Jennifer M., Shaham, Yavin, Harvey, Brandon K., Olivia M. Lofaro, Richie, Christopher T., Hyeon Son, Li, Xuan, Son, Hyeon, Zeric, Tamara, Carreria, Maria B., Eric J. Nestler, Cowan, Christopher W., Nestler, Eric J., Surjono, Felicia, Xuan Li, Jennifer M. Bossert, Maria B. Carreria, Christopher W. Cowan, Lofaro, Olivia M., Christopher T. Richie, Witonsky, Kailyn R., Zhang, Jianjun, Tamara Zeric, Yavin Shaham, Felicia Surjono, Kailyn R. Witonsky, Brandon K. Harvey   +27 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source