Results 31 to 40 of about 217,123 (303)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
, 1926 The Passaic Strike of 1926 began on January 25, 1926, at the Botany Mill in Passaic when six thousand workers went on ...
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
DRONE OPERATORS – LEGAL RESPONSIBILITY [PDF]
Challenges of the Knowledge Society, 2016 Drones or unmanned or remote vehicles represent a new generation of devices that were designed to help mankind achieve better results in areas that were proven to hazardous.
Andrei-Alexandru STOICA
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Les mouvements sociaux en Martinique dans les années 1960 et la réaction des pouvoirs publics
Études Caribéennes, 2010 Social conflict in the West Indies in 2009 was highly publicized in France where it seemed exceptional, as a first event in the social field likely to shake the authority of a government previously inflexible in this area.
Laurent Jalabert
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
THE IMPACT OF ECONOMIC INFRASTRUCTURE ON LONG TERM ECONOMIC GROWTH IN BOTSWANA
Journal of Smart Economic Growth, 2017 The growth rate for the Botswana economy has slowed down in recent years. This has been explained by weak global demand in minerals, subdued commodity prices and persistent electricity supply problems.
Strike Mbulawa
doaj
Hétérodoxie anarchiste en Argentine : analyse d’une déviance contre-démocratique
Nuevo mundo - Mundos Nuevos, 2009 The golden age of the anarchist movement in Argentina (1890-1930) can be defined as the rise of a counter-democratic force that puts at stake the elites’ power at the same time that it builds the basis of a parallel society sustained by alternative ...
Hélène Finet
doaj +1 more source