Results 51 to 60 of about 217,123 (303)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Study Design and Testing of Structural Configurations for the bird-strike compliance of aeronautical components [PDF]
, 2008 This work is the result of a collaborative research project between the univer- sity (Department of Aerospace Engineering at University of Naples "Federico II") and an industrial partner (Alenia Aeronautica at Pomigliano d'Arco).
Guida, Michele, M. Guida
core +1 more source
La Nouvelle Revue du Travail, 2016 Understanding the modalities by means of which collective bargaining develops not only requires analysis of employers’ negotiation avoidance practices but also a review of the evisceration tactics they pursue to minimise the scope of these exchanges ...
Baptiste Giraud, Rémy Ponge
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Contraddizioni e antinomie nella regolazione dello sciopero nei servizi pubblici essenziali [PDF]
Democrazia e Diritti Sociali, 2023 The study analyses the Italian regulation of the right to strike in essential services. It reviews the restrictive interpretations, weakening conflict and trade unions.
Marialaura Birgillito
doaj
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Longitudinal Analysis of Strike Activity [PDF]
This paper presents evidence on two aspects of strike activity associated with the renegotiation of union contracts: the effects of contract characteristics on dispute probabilities; and the effects of lagged strike outcomes on the incidence and duration
David Card
core
Alliances et autonomie politique. Les deux faces du syndicalisme chilien
Cahiers des Amériques Latines, 2017 Chile has experienced in the last decade an increase of the labor conflict, with special protagonism of the workers mobilized in illegal strikes. Based on interviews with leaders of 43 strikes held in 2014 and complemented by statistical data, three ...
Rodrigo Medel Sierralta
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source