Results 111 to 120 of about 217,958 (282)

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

String Corrected Spacetimes and SU(N)-Structure Manifolds

Nuclear Physics B, 2015
27 ...
Becker, Katrin, Becker, Melanie, Robbins, Daniel   +2 more
openaire   +3 more sources

A Self‐Organized Liquid Reaction Container for Cellular Memory

Advanced Science, EarlyView.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee, Enrico Skoruppa, Holger Merlitz, Jens‐Uwe Sommer, Helmut Schiessel   +4 more
wiley   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

GUP corrected black holes with cloud of string

European Physical Journal C: Particles and Fields
We investigate shadows, deflection angle, quasinormal modes (QNMs), and sparsity of Hawking radiation of the Schwarzschild string cloud black hole’s solution after applying quantum corrections required by the Generalised Uncertainty Principle (GUP ...
Ahmad Al-Badawi, Sanjar Shaymatov, Sohan Kumar Jha, Anisur Rahaman   +3 more
doaj   +1 more source

M-theory beyond the supergravity approximation

Journal of High Energy Physics, 2018
We analyze the four-point function of stress-tensor multiplets for the 6d quantum field theory with OSp(8∗|4) symmetry which is conjectured to be dual to M-theory on AdS 7 × S 4, and deduce the leading correction to the tree-level supergravity prediction
Paul Heslop, Arthur E. Lipstein
doaj   +1 more source

Charge and reduce: A fixed-parameter algorithm for String-to-String Correction

Discrete Optimization, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Abu-Khzam, Faisal N., Fernau, Henning, Langston, Micheal A., Lee-Cultura, Serena, Stege, Ulrike   +4 more
openaire   +2 more sources

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

An HHL 3-point correlation function in the η-deformed AdS5×S5

Physics Letters B, 2015
We derive the 3-point correlation function between two giant magnons heavy string states and the light dilaton operator with zero momentum in the η-deformed AdS5×S5 valid for any J1 and η in the semiclassical limit.
Changrim Ahn, Plamen Bozhilov
doaj   +1 more source

Membrany corrections to the string anti-string potential in M5-brane theory [PDF]

Journal of High Energy Physics, 1999
12 pages, with 2 figures, harvmac big, v2: typos corrected and discussion in end of sec 3 added, v3: version in JHEP, v4: typo in equ.
openaire   +2 more sources