Results 121 to 130 of about 217,958 (282)
Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition
Advanced Science, EarlyView.Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han +9 more
wiley +1 more source
A Note on Noncommutative String theory and its low energy limit
, 2001 The noncommutative string theory is described by embedding open string theory in a constant second rank antisymmetric $B_{\mu\nu}$ field and the noncommutative gauge theory is defined by a deformed $\star$ product. As a check, study of various scattering
Schomerus V. +3 more
core +2 more sources
Advanced Science, EarlyView.Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang +16 more
wiley +1 more source
Massive spectrum in F-theory and the distance conjecture
Journal of High Energy PhysicsWe investigate the massive states in F-theory compactification models, including BPS string junctions stretching between parallel 7-branes and KK modes. We obtain analytical results when there are two colliding bunches of 7-branes with a locally constant
Keren Chen, Qinjian Lou, Yi-Nan Wang
doaj +1 more source
Error-tolerant Finite State Recognition with Applications to Morphological Analysis and Spelling Correction [PDF]
, 1995 Error-tolerant recognition enables the recognition of strings that deviate mildly from any string in the regular set recognized by the underlying finite state recognizer.
Oflazer, Kemal
core +6 more sources
String Quantization in Curved Spacetimes: Null String Approach
, 1994 We study quantum strings in strong gravitational fields. The relevant small parameter is $g=R_c{\sqrt T_0}$, where $R_c$ is the curvature of the spacetime and $T_0$ is the string tension. Within our systematic expansion we obtain to zeroth order the null
de Vega, H. J. +2 more
core +1 more source
Advanced Science, EarlyView.This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang +10 more
wiley +1 more source
Журнал Белорусского государственного университета: Математика, информатика, 2018 A method is proposed for correcting of test classical solutions of the general inhomogeneous factorized oscillation equation for a semibounded string in order that they have minimal (necessary) smoothness requirements on its righthand side.
Fiodar E. Lomautsau
doaj
Demystifying the Emergence Proposal
Journal of High Energy PhysicsWe revisit the Emergence Proposal in the vector multiplet moduli space of type IIA N = 2 supersymmetric string vacua in four dimensions, for which the string tree-level prepotential and the string one-loop correction are exactly known via mirror symmetry.
Ralph Blumenhagen +3 more
doaj +1 more source
Advanced Science, EarlyView.BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou +9 more
wiley +1 more source