Results 311 to 320 of about 1,577,348 (378)

Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
Macrophages stimulated by BCG significantly enhanced endothelial cell proliferation, migration, and tube formation. Mechanistically, this pro‐angiogenic activity was reliant on activating NF‐αB or other signaling pathways, which induced the upregulation of HIF‐1α and VEGFA.
Yuyang Hou, Yuxi Wang, Qiong Wu, Wenjing Du, Shanzhu Guo, Xinyu Chai, Yinan Wang, Huixin Liang, Hongyan Yuan, Jun Li, Dongmei Yan   +10 more
wiley   +1 more source

The immune duality of osteopontin and its therapeutic implications for kidney transplantation. [PDF]

Front Immunol
Leung J, Qu L, Ye Q, Zhong Z.
europepmc   +1 more source

TargetGen‐RNN model discovers novel antibiotic compound targeting drug‐resistant Staphylococcus aureus

Interdisciplinary Medicine, EarlyView.
TargetGen‐recurrent neural network (RNN), an advanced generative model, generated 28,708 unique and novel compounds, identifying SAK‐2970 as a potent antibiotic against drug‐resistant Staphylococcus aureus. Exhibiting strong biofilm inhibition, high therapeutic efficacy, and minimal systemic toxicity in vivo, SAK‐2970 highlights its safety and clinical
Shakeel Ahmad Khan, Adnan Shakoor, Sadia Kanwal   +2 more
wiley   +1 more source

Expression Characteristics and Prognostic Value of KLRG2 in Endometrial Cancer: A Comprehensive Analysis Based on Multi-Omics Data. [PDF]

Biomedicines
Huang X, Li A, Xu D.
europepmc   +1 more source

Adolescent Anxiety During the COVID‐19 Pandemic: A Qualitative Systematic Review of Risk and Protective Factors

Journal of Adolescence, EarlyView.
ABSTRACT Introduction The COVID‐19 pandemic significantly disrupted adolescents' lives, leading to increased stress and anxiety rates globally. Although existing research highlights the necessity of understanding the increased rates of anxiety in adolescents during and after the pandemic, it offers little insight into the risk and protective factors ...
Buket Kara, Nitzan Scharf, Kathleen McCormack, Linda Bhreathnach, Candace Currie, Jennifer Symonds   +5 more
wiley   +1 more source

Comprehensive bioinformatics and <i>in vivo</i> validation reveal key molecular drivers of diabetic nephropathy progression. [PDF]

Front Endocrinol (Lausanne)
Yang Y, He X, Liu W, Mu L, Wang S.
europepmc   +1 more source

The A(I) Team: Effects of Human‐Likeness and Conformity to Gender Stereotypes on Initial Trust and Willingness to Work With an AI Teammate

Journal of Organizational Behavior, EarlyView.
ABSTRACT As artificial intelligence (AI) technologies progress, AI agents arise as potential teammates in the workplace. This study explores how the visual representation of the AI agent as well as its conformity to traditional gender stereotypes affects the manifestation of uncanny valley effects in a workplace team context.
Agata Mirowska, Jbid Arsenyan
wiley   +1 more source

Massless and massive scalar shell dynamics from rotating BTZ black holes with nonminimally coupled scalar fields. [PDF]

Sci Rep
Javed F, Waseem A, Mustafa G, Maurya SK, Shrahili M, Atamurotov F, Ashebo MA.   +6 more
europepmc   +1 more source

Thermal Duality Confronts Entropy: A New Approach to String Thermodynamics?

, 2003
Keith R. Dienes, Michael Lennek
openalex   +2 more sources

Executive Function and Entrepreneurial Opportunity Exploitation Under Risk and Uncertainty

Strategic Change, EarlyView.
ABSTRACT This study examines how executive functions shape entrepreneurial opportunity exploitation under different knowledge environments. Drawing on Knight's distinction between risk and uncertainty, we conducted a vignette experiment with 200 working adults.
Ipek Koparan, Gorkem Aksaray, Tatiana Manolova, Linda Edelman   +3 more
wiley   +1 more source