Results 71 to 80 of about 6,694,171 (343)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Burg-Metzner-Sachs symmetry, string theory, and soft theorems [PDF]
, 2015 We study the action of the BMS group in critical, bosonic string theory living on a target space of the form $\mathbb{M}^{d}\times C$. Here $M^{d}$ is $d$-dimensional (asymptotically) flat spacetime and $C$ is an arbitrary compactification.
Steven G. Avery, Burkhard U. W. Schwab
semanticscholar +1 more source
Towards inflation in string theory [PDF]
Journal of Cosmology and Astroparticle Physics, 2003 I will discuss the development of inflationary theory and its present status, including recent progress in describing de Sitter space and inflationary universe in string theory.
S. Kachru +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
A tale of two exponentiations in N $$ \mathcal{N} $$ = 8 supergravity at subleading level
Journal of High Energy Physics, 2020 High-energy massless gravitational scattering in N $$ \mathcal{N} $$ = 8 supergravity was recently analyzed at leading level in the deflection angle, uncovering an interesting connection between exponentiation of infrared divergences in momentum space ...
Paolo Di Vecchia +4 more
doaj +1 more source
On the equivalence of fermionic string to bosonic string in two dimensions
, 1995 Two-dimensional fermionic string theory is shown to have a structure of topological model, which is isomorphic to a tensor product of two topological ghost systems independent of each other.
Berkovits +32 more
core +1 more source
On natural inflation and moduli stabilisation in string theory [PDF]
, 2015 A bstractNatural inflation relies on the existence of an axion decay constant which is super-Planckian. In string theory only sub-Planckian axion decay constants have been found in any controlled regime. However in field theory it is possible to generate
Eran Palti
semanticscholar +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Journal of High Energy Physics, 2021 The double copy relates scattering amplitudes and classical solutions in Yang-Mills theory, gravity, and related field theories. Previous work has shown that this has an explicit realisation in self-dual YM theory, where the equation of motion can be ...
Erick Chacón +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source