Results 171 to 180 of about 148,082 (308)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Triple-Level Content-Addressable Vertical NAND Flash Memory. [PDF]

Adv Sci (Weinh)
Park SH, Im J, Yang Y, Koo RH, Ko J, Oh M, Shin D, Jung G, Lee JH.   +8 more
europepmc   +1 more source

No-Strings Representationalism

, 2003
Opinion is still divided over the role that internal world models can play in autonomous behaviour. Researchers who dispute the necessity of such models often have a restricted view of how they are constituted and may associate the whole enterprise of
No-strings Representationalism, Chris Thornton Cognitive, Chris Thornton, Bn Qh   +3 more
core  

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Courtship Behavior and Induced Spawning Dynamics of the Freshwater Shark, <i>Wallago attu</i>, in Captivity: Implications for Silurid Reproductive Strategies. [PDF]

Animals (Basel)
Khan SA, Khan MKA, Sherzada S, Nazir MM, Yaseen R, Bhatti MB, Majeed MS, Riaz S, Mansour AT, Hussain T, Nowosad J, Kucharczyk D.   +11 more
europepmc   +1 more source

Strings Society song lyrics and sheet music (circa 1983)

This collection contains typed lyrics and handwritten musical notation for songs performed by members of the Strings Society at Wake Forest University. The materials include society anthems such as "Sisterhood Song," "String Along the Open Road," and "Up

core  

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

The "Lost" and "Found" IUD: a case of concurrent intrauterine and intraperitoneal devices with delayed recognition. [PDF]

Int J Surg Case Rep
Alfaraj AM, Al-Darwish AS, Saffaf MK, AlHawassi S.   +3 more
europepmc   +1 more source

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source