Results 41 to 50 of about 94,076 (308)

The Virtual International Stroke Trials Archive [PDF]

, 2007
Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal.
Donnan, Geoffrey A., Kaste, M., HENNERICI, Michael G, Teal, P., Gregson, B.A., Hacke, Werner, Marler, J.R., Marler, John R., Fisher, M., GREGSON, Barbara A, Wahlgren, Nils-Gunnar, Curram, John, Grotta, J., MARLER, John R, Davis, Stephen M., Sacco, Ralph L., Donnan, G.A., Myzoon, Ali, Bath, Philip M.W., Teal, Philip, WEIR, Christopher J, Weir, C.J., Gregson, Barbara A., Fisher, Marc, Hommel, Marc, Hacke, W., BATH, Philip M. W, Sacco, R.L., Diener, Hans-Christoph, Warach, S., DONNAN, Geoffrey A, Hennerici, Michael G., Wahlgren, N.-G., Lees, K.R., Grotta, James, Hennerici, M.G., Kaste, Markku, Weir, Christopher J., Warach, Steven, Lees, Kennedy R., DAVIS, Stephen M, Bath, P.M.W., Ali, M., Curram, J., Diener, H.-C., Ali, Myzoon, Davis, S.M., SACCO, Ralph L, Hommel, M., LEES, Kennedy R   +49 more
core   +1 more source

Outcome after acute ischemic stroke is linked to sex-specific lesion patterns [PDF]

, 2021
Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men.
MRI-GENIE & GISCOME Investigators, Int Stroke Genetics Consortium, Schirmer, Markus D., Tatlisumak, Turgut, Bonkhoff, Anna K., McArdle, Patrick F., Strbian, Daniel   +6 more
core   +2 more sources

Determinants of post-stroke depression among stroke survivors at University of Gondar Hospital, Northwest Ethiopia: a case-control study

BMC Neurology, 2022
Background Stroke is one of the most common causes of disability among adults. Post-stroke depression (PSD) is a frequent neuropsychiatric complication in stroke patients. Despite the increasing prevalence of stroke, there is a paucity of data on PSD and
Ephrem Fantu, Workagegnehu Hailu, Nebiyu Bekele, Tewodros Tsegaye, Melaku Tadesse, Mezgebu Silamsaw Asres   +5 more
doaj   +1 more source

Cerebral small vessel disease and stroke: linked by stroke aetiology, but not stroke lesion location or size. [PDF]

BACKGROUND Cerebral small vessel disease (SVD) has previously been associated with worse stroke outcome, vascular dementia, and specific cognitive deficits. The underlying causal mechanisms of these associations are not yet fully understood.
Hakim, Arsany, Arnold, Marcel, Sperber, Christoph, Gallucci, Laura, Umarova, Roza M   +4 more
core   +1 more source

Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome [PDF]

, 2014
Ischemic stroke (IS) outcome predictors include clinical features, biochemical parameters and some risk factors. The relations between two main players in the ischemic brain, MMPs and HMGB1, were estimated in the plasma of ischemic stroke patients ...
Kalandadze, Iagor, Gugutsidze, Darejan, Shakarishvili, Roman, Sapojnikova, Nelly, Kartvelishvili, Tamar, Zinkevich, Vitaly, Tsiskaridze, Alexander, Asatiani, Nino   +7 more
core   +1 more source

Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury

Journal of Neuroinflammation, 2012
Background Using a live imaging approach, we have previously shown that microglia activation after stroke is characterized by marked and long-term induction of the Toll-like receptor (TLR) 2 biophotonic signals. However, the role of TLR2 (and potentially
Bohacek Ivan, Cordeau Pierre, Lalancette–Hébert Mélanie, Gorup Dunja, Weng Yuan-Cheng, Gajovic Srecko, Kriz Jasna   +6 more
doaj   +1 more source

Unravelling the Genetics of Ischaemic Stroke

, 2010
Epidemiological studies suggest genetic predisposition is important in stroke risk. Monogenic conditions are important for the individual patient but do not account for much population attributable risk. An increasing number of such conditions are being
Hugh S Markus, Markus Hugh S., Markus, HS   +2 more
core   +1 more source

CADASIL: A monogenic condition causing stroke and subcortical vascular dementia [PDF]

, 2002
Mutations in Notch3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited small vessel disease leading to subcortical strokes and vascular dementia. The phenotypic presentation
Dichgans, Martin
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Mechanisms of Cognitive Impairment in Cerebral Small Vessel Disease: Multimodal MRI Results from the St George's Cognition and Neuroimaging in Stroke (SCANS) Study. [PDF]

, 2013
Cerebral small vessel disease (SVD) is a common cause of vascular cognitive impairment. A number of disease features can be assessed on MRI including lacunar infarcts, T2 lesion volume, brain atrophy, and cerebral microbleeds.
Lawrence, AJ, Barrick, Thomas R., Lawrence Andrew J., Barrick Thomas R., Andrew J Lawrence, Robin G Morris, MacKinnon, Andrew D., Hugh S. Markus, Thomas R Barrick, Bhavini Patel, Robin G. Morris, MacKinnon, AD, Bhavini Patel (405150), Barrick, TR, Philip M. Rich (405153), Markus, HS, Andrew D. MacKinnon, Rich, PM, Thomas R. Barrick (405154), Thomas R. Barrick, Hugh S Markus, Lawrence, Andrew J.; id_orcid, Patel, B, Andrew J. Lawrence, MacKinnon Andrew D., Rich, Philip M., Hugh S. Markus (366687), Andrew J. Lawrence (292444), Robin G. Morris (405151), Morris, RG, Patel Bhavini, Morris Robin G., Morris, Robin G., Andrew D MacKinnon, Rich Philip M., Patel, Bhavini, Philip M Rich, Andrew D. MacKinnon (405152), Markus Hugh S., Philip M. Rich, Markus, Hugh S.   +40 more
core   +1 more source