Results 141 to 150 of about 1,456,101 (307)

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Stroke and its management in Australia: an update [PDF]

, 2013
This report presents a comprehensive picture about, and the latest data on, stroke and how it is managed in Australia.SummaryStroke poses a burden on patients, their families and servicesAlthough stroke event rates fell by 25% between 1997 and 2009, the ...

core  

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Significance of atherosclerotic plaque location in recanalizing non-acute long-segment occlusion of the internal carotid artery

Scientific Reports
To investigate the significance of atherosclerotic plaque location in hybrid surgery comprising both endovascular recanalization approaches and carotid endarterectomy for symptomatic atherosclerotic non-acute long-segment occlusion of the internal ...
Tong-Yuan Zhao, Gang-Qin Xu, Jiang-Yu Xue, Wei-Xing Bai, Dong-Yang Cai, Bo-Wen Yang, Wei-Yu Shi, Tian-Xiao Li, Bu-Lang Gao   +8 more
doaj   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

Risk, Uncertainty and Life Threatening Trauma: Analysing Stroke Survivor's Accounts of Life after Stroke [PDF]

, 2006
This paper examines the ways in which stroke survivors identify and manage the risks and uncertainties of their situation. It draws on interview data from a UK study in East Kent of 31 stroke survivors (aged between 38 and 89 years).
Helen Alaszewski, Jonathan Potter, Alaszewski, Helen P., Potter, Jonathan, Andy Alaszewski, Alaszewski, Andy   +5 more
core  

Clinico-radiological features of intracranial atherosclerosis-related large vessel occlusion prior to endovascular treatment

Scientific Reports
The identification of large vessel occlusion with underlying intracranial atherosclerotic disease (ICAS-LVO) before endovascular treatment (EVT) continues to be a challenge. We aimed to analyze baseline clinical-radiological features associated with ICAS-
Marc Rodrigo-Gisbert, Alvaro García-Tornel, Manuel Requena, Isabel Vielba-Gómez, Saima Bashir, Marta Rubiera, Marta De Dios Lascuevas, Marta Olivé-Gadea, Carlos Piñana, Federica Rizzo, Marian Muchada, Noelia Rodriguez-Villatoro, David Rodríguez-Luna, Jesus Juega, Jorge Pagola, David Hernández, Carlos A. Molina, Mikel Terceño, Alejandro Tomasello, Marc Ribo   +19 more
doaj   +1 more source

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Effects of percutaneous endovascular angioplasty for severe stenosis or occlusion of subclavian artery

Scientific Reports
To investigate the effect and safety of percutaneous endovascular angioplasty (PEA) with optional stenting for the treatment of severe stenosis or occlusion of subclavian artery, patients with severe stenosis ≥ 70% or occlusion of subclavian artery ...
Tong-Yuan Zhao, Gang-Qin Xu, Jiang-Yu Xue, Dong-Yang Cai, Bo-Wen Yang, Yue-Yang Ba, Chen-Yi Feng, Tian-Xiao Li, Bu-Lang Gao, Zhong-Can Chen   +9 more
doaj   +1 more source