Results 31 to 40 of about 2,146,909 (263)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Association of Birthplace and Coronary Heart Disease and Stroke Among US Adults: National Health Interview Survey, 2006 to 2014

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe proportion of foreign‐born US adults has almost tripled since 1970. However, less is known about the cardiovascular morbidity by birthplace among adults residing in the United States.
Jing Fang, Keming Yuan, Renee M. Gindi, Brian W. Ward, Carma Ayala, Fleetwood Loustalot   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

XANTUS: rationale and design of a noninterventional study of rivaroxaban for the prevention of stroke in patients with atrial fibrillation [PDF]

, 2014
A John Camm,1 Pierre Amarenco,2 Sylvia Haas,3 Susanne Hess,4 Paulus Kirchhof,5,6 Martin van Eickels,4 Alexander GG Turpie71Division of Clinical Sciences, St George's, University of London, London, UK; 2Department of Neurology and Stroke Center, Paris-
Hess, S, Camm, AJ, Amarenco, Pierre, Eickels MV, Turpie, AG, Hess, Susanne, Haas, S, Turpie, Alexander G G, Kirchhof, P, van Eickels, M, Haas, Sylvia, Kirchhof, Paulus; id_orcid, Amarenco, P, Camm AJ, Hess S, Camm, John, Amarenco P, Van Eickels, Martin, Turpie AGG, Kirchhof P, Haas S   +20 more
core   +1 more source

Changes in blood pressure measurement prevalence among United States adults with hypertension before and during the COVID-19 pandemic

Preventive Medicine Reports
Background: The Coronavirus Disease 2019 (COVID-19) pandemic disrupted health care, with particularly profound effects on persons with chronic conditions like hypertension.
Baffour Otchere, Adam S. Vaughan, LaTonia Richardson, Hilary K. Wall, Fátima Coronado   +4 more
doaj   +1 more source

Initiatives to Enhance Primary Care Delivery

Health Services Research & Managerial Epidemiology, 2015
Objectives: Increasing demands on primary care providers have created a need for systems-level initiatives to improve primary care delivery. The purpose of this article is to describe and present outcomes for 2 such initiatives: the Pennsylvania Academy ...
Jan L. Losby, Marnie J. House, Thearis Osuji, Sarah Abood O’Dell, Alberta M. Mirambeau, Joanna Elmi, Eileen Chappelle, Dara F. Schlueter   +7 more
doaj   +1 more source

Exercise with a wearable hip-assist robot improved physical function and walking efficiency in older adults

Scientific Reports, 2023
Wearable assistive robotics has emerged as a promising technology to supplement or replace motor functions and to retrain people recovering from an injury or living with reduced mobility.
Su-Hyun Lee, Jihye Kim, Bokman Lim, Hwang-Jae Lee, Yun-Hee Kim   +4 more
doaj   +1 more source

Changes in Cortical Activity during Preferred and Fast Speed Walking under Single- and Dual-Tasks in the Young-Old and Old-Old Elderly

Brain Sciences, 2021
In the elderly, walking while simultaneously engaging in other activities becomes more difficult. This study aimed to examine the changes in cortical activity during walking with aging.
Jinuk Kim, Gihyoun Lee, Jungsoo Lee, Yun-Hee Kim   +3 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Transcranial Doppler After Endovascular Treatment to Evaluate Collateral Status and Outcomes in Patients With Large‐Vessel Occlusion

Stroke: Vascular and Interventional Neurology, 2022
Background Recent advances in endovascular therapy (EVT) have led to significant improvements in functional outcomes of patients with stroke. However, early neurological deterioration after EVT has remained a concerning issue.
Reza Bavarsad Shahripour, Mahmoud Reza Azarpazhooh, Humayon Akhuanzada, Jason W. Tarpley, Afshin Borhani‐Haghighi, Kunal Agrawal, Royya Modir, Brett Meyer, Thomas M Hemmen, Dawn Meyer   +9 more
doaj   +1 more source