Results 51 to 60 of about 2,146,909 (263)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

European Stroke Organisation (ESO) guidelines for the management of temperature in patients with acute ischemic stroke.

, 2015
Hyperthermia is a frequent complication in patients with acute ischemic stroke. On the other hand, therapeutically induced hypothermia has shown promising potential in animal models of focal cerebral ischemia.
European Stroke, Organisation, Thomas, Brenda, Steiner, Thorsten, European Stroke Organisation,, Petersson, Jesper,, Ntaios, George, Steiner, T., Petersson, Jesper, Staykov, D., Papavasileiou, Vasileios, Staykov, Dimitre, Papavasileiou, V., Ntaios, G., Thomas, B., Lund University., Dziedzic, Tomasz, Michel, Patrik, Dziedzic, T., Michel, P., Petersson, J.   +19 more
core   +1 more source

Think FAST: Knowledge of Appropriate Action of Stroke Signs and Symptoms Among US Adults, February–March 2025

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The Facial drooping, Arm weakness, Speech difficulty, Time to call 911 (FAST) mnemonic raises awareness of common stroke signs and symptoms and reinforces the urgency of activating emergency services. We examined the prevalence of knowledge of
Adam S. Vaughan, Tatyana Valteau, Sandra L. Jackson, Hilary K. Wall, Fleetwood Loustalot, Fátima Coronado   +5 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Surveillance and evaluation data resource guide for heart disease and stroke prevention programs [PDF]

High blood pressure, high sodium intake, high cholesterol, and smoking continue to put more people at risk of heart disease and stroke. To address these risk factors, the CDC focuses on the ABCS of heart disease and stroke prevention\u2014appropriate ...

core   +2 more sources

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

The evidence-base for stroke education in care homes [PDF]

, 2008
<b>Summary.</b> <b>Research questions:</b> 1. What are registered care home nurses’ educational priorities regarding stroke care? 2. What are senior care home assistants’ educational priorities regarding stroke care? 3. How do
Smith, L.N., Weir, C.J., Craig, L.E., McAlpine, C.H.   +3 more
core   +1 more source

Associations of blood biomarkers with glomerular filtration rate in patients with TIA and stroke: population-based study

Stroke and Vascular Neurology
Background and purpose Non-traditional risk factors such as chronic inflammation, oxidative stress and thrombogenic factors are believed to contribute to the excess stroke risk in chronic kidney disease (CKD) by triggering vascular injury and endothelial
Dearbhla M. Kelly, Peter M. Rothwell, Linxin Li, Annette I Burgess, Deborah L Poole, Julia M Duerden   +5 more
doaj   +1 more source

Weights for ordinal analyses of the modified Rankin Scale in stroke trials: A population-based cohort study

EClinicalMedicine, 2020
Background: Ordinal/shift analyses of ordered measures like the modified Rankin Scale(mRS) are underused as primary trial outcomes for neurological disorders – despite statistical advantages – potentially hindered by poor clinical interpretability versus
Aravind Ganesh, Ramon Luengo-Fernandez, Sarah T. Pendlebury, Peter M. Rothwell   +3 more
doaj   +1 more source