Results 51 to 60 of about 10,980,441 (384)
Are mesenchymal stromal cells immune cells? [PDF]
Arthritis Research & Therapy, 2015 AbstractMesenchymal stromal cells (MSCs) are considered to be promising agents for the treatment of immunological disease. Although originally identified as precursor cells for mesenchymal lineages, in vitro studies have demonstrated that MSCs possess diverse immune regulatory capacities.
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A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk. [PDF]
, 2020 BackgroundTumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and a single ...
Azizi, Armon +19 more
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Nature Materials, 2019 Hydrogels serve as valuable tools for studying cell–extracellular matrix interactions in three-dimensional environments that recapitulate aspects of native extracellular matrix.
Claudia Loebel, R. Mauck, J. Burdick
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Mesenchymal stromal cells in the thymus
Inflammation and Regeneration, 2022 AbstractThe microenvironment of the thymus is composed of a group of stromal cells that include endoderm-derived thymic epithelial cells (TECs) and mesenchymal stromal cells such as fibroblasts and serves as a site for the development of T cells. TECs are known to play an essential role in T cell differentiation and selection. Mesenchymal stromal cells
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Frontiers in Bioengineering and Biotechnology, 2020 Mesenchymal stromal cell senescence and apoptosis have been identified as critical molecular hallmarks in aging. In this study, we used stromal cell sheet culture as an in vitro model to study the progressive changes of cellular senescence, apoptosis and
Ying Xu +6 more
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Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin [PDF]
, 2005 Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis ( RA) by assessing a ...
A Bucht +65 more
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Remodeling of Stromal Cells and Immune Landscape in Microenvironment During Tumor Progression
Frontiers in Oncology, 2021 The molecular understanding of carcinogenesis and tumor progression rests in intra and inter-tumoral heterogeneity. Solid tumors confined with vast diversity of genetic abnormalities, epigenetic modifications, and environmental cues that differ at each ...
Leena Arora, Durba Pal
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Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples [PDF]
, 2013 Emerging evidence has shown that the tumor microenvironment plays a crucial role in prostate cancer (PCa) development and progression. However, the mechanism(s) through which stromal cells regulate epithelial cells and the differences among prostatic ...
Clemente, Luigi Di +7 more
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Mechanisms of mesenchymal stem/stromal cell function
Stem cell research & therapeutics, 2016 The past decade has seen an explosion of research directed toward better understanding of the mechanisms of mesenchymal stem/stromal cell (MSC) function during rescue and repair of injured organs and tissues.
Jeffrey L Spees, R. Lee, C. Gregory
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Frontiers in Molecular Biosciences, 2023 Adenocarcinoma not otherwise specified (AC) and mucinous adenocarcinoma (MC) have different biological behaviors and clinical features. We utilized our previous proteomic data and public transcriptome, single-cell transcriptome, and spatial transcriptome
Kailun Xu +4 more
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