Results 51 to 60 of about 10,980,441 (384)

Are mesenchymal stromal cells immune cells? [PDF]

open access: yesArthritis Research & Therapy, 2015
AbstractMesenchymal stromal cells (MSCs) are considered to be promising agents for the treatment of immunological disease. Although originally identified as precursor cells for mesenchymal lineages, in vitro studies have demonstrated that MSCs possess diverse immune regulatory capacities.
openaire   +3 more sources

A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk. [PDF]

open access: yes, 2020
BackgroundTumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and a single ...
Azizi, Armon   +19 more
core   +4 more sources

Local nascent protein deposition and remodeling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels

open access: yesNature Materials, 2019
Hydrogels serve as valuable tools for studying cell–extracellular matrix interactions in three-dimensional environments that recapitulate aspects of native extracellular matrix.
Claudia Loebel, R. Mauck, J. Burdick
semanticscholar   +1 more source

Mesenchymal stromal cells in the thymus

open access: yesInflammation and Regeneration, 2022
AbstractThe microenvironment of the thymus is composed of a group of stromal cells that include endoderm-derived thymic epithelial cells (TECs) and mesenchymal stromal cells such as fibroblasts and serves as a site for the development of T cells. TECs are known to play an essential role in T cell differentiation and selection. Mesenchymal stromal cells
openaire   +3 more sources

Wnt Signaling Inhibits High-Density Cell Sheet Culture Induced Mesenchymal Stromal Cell Aging by Targeting Cell Cycle Inhibitor p27

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
Mesenchymal stromal cell senescence and apoptosis have been identified as critical molecular hallmarks in aging. In this study, we used stromal cell sheet culture as an in vitro model to study the progressive changes of cellular senescence, apoptosis and
Ying Xu   +6 more
doaj   +1 more source

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin [PDF]

open access: yes, 2005
Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis ( RA) by assessing a ...
A Bucht   +65 more
core   +2 more sources

Remodeling of Stromal Cells and Immune Landscape in Microenvironment During Tumor Progression

open access: yesFrontiers in Oncology, 2021
The molecular understanding of carcinogenesis and tumor progression rests in intra and inter-tumoral heterogeneity. Solid tumors confined with vast diversity of genetic abnormalities, epigenetic modifications, and environmental cues that differ at each ...
Leena Arora, Durba Pal
doaj   +1 more source

Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples [PDF]

open access: yes, 2013
Emerging evidence has shown that the tumor microenvironment plays a crucial role in prostate cancer (PCa) development and progression. However, the mechanism(s) through which stromal cells regulate epithelial cells and the differences among prostatic ...
Clemente, Luigi Di   +7 more
core   +1 more source

Mechanisms of mesenchymal stem/stromal cell function

open access: yesStem cell research & therapeutics, 2016
The past decade has seen an explosion of research directed toward better understanding of the mechanisms of mesenchymal stem/stromal cell (MSC) function during rescue and repair of injured organs and tissues.
Jeffrey L Spees, R. Lee, C. Gregory
semanticscholar   +1 more source

Molecular characterization of colorectal mucinous adenocarcinoma and adenocarcinoma, not otherwise specified, identified by multiomic data analysis

open access: yesFrontiers in Molecular Biosciences, 2023
Adenocarcinoma not otherwise specified (AC) and mucinous adenocarcinoma (MC) have different biological behaviors and clinical features. We utilized our previous proteomic data and public transcriptome, single-cell transcriptome, and spatial transcriptome
Kailun Xu   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy