Results 131 to 140 of about 1,202,304 (236)

Using evolutionary context to classify difficult protein folds. [PDF]

PLoS Comput Biol
Pei J, Schaeffer RD, Cong Q, Grishin NV.
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

IS<i>Aba1</i>-mediated <i>bla</i>_ADC disruption restores third-generation cephalosporin susceptibility in a clinical <i>Acinetobacter baumannii</i> isolate. [PDF]

Antimicrob Agents Chemother
Nodari CS, Bai Q, Cayô R, Streling AP, Alberto-Lei F, Wille J, C Pignatari AC, Seifert H, Gales AC, Higgins PG.   +9 more
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Aging impairs peroxisome biogenesis in human B cells. [PDF]

J Gerontol A Biol Sci Med Sci
Correia J, Roy PS, Holden KG, Kohut ML, Bai H.   +4 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Metatranscriptomic-driven insights into mucosal glycan degradation by the human gut microbiota. [PDF]

FEMS Microbiol Ecol
Bauchinger F, Berry D.
europepmc   +1 more source

Type beta transforming growth factor is an inhibitor of myogenic differentiation.

Proceedings of the National Academy of Sciences of the United States of America, 1986
J. Massagué, S. Cheifetz, T. Endo, B. Nadal-Ginard   +3 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Variation in Uterine and Serum Proteins During the Reproductive Cycle in Dairy Cows Following Low and High Dietary Protein Intake. [PDF]

Vet Med Sci
Pirestani A, Motalebipour EZ.
europepmc   +1 more source