Results 141 to 150 of about 6,198,727 (341)

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

open access: yesMolecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park   +6 more
wiley   +1 more source

The Strong Consistency of the Estimator of Fixed-Design Regression Model under Negatively Dependent Sequences

open access: yesAbstract and Applied Analysis, 2013
We study the strong consistency of estimator of fixed design regression model under negatively dependent sequences by using the classical Rosenthal-type inequality and the truncated method.
Xuejun Wang   +3 more
doaj   +1 more source

A Preliminary Model of Coordination-free Consistency [PDF]

open access: yesarXiv
Building consistent distributed systems has largely depended on complex coordination strategies that are not only tricky to implement, but also take a toll on performance as they require nodes to wait for coordination messages. In this paper, we explore the conditions under which no coordination is required to guarantee consistency. We present a simple
arxiv  

Strongly meager and strong measure zero sets [PDF]

open access: yesarXiv, 1999
We show that the following are consistent with ZFC: 1. Strongly meager sets form an ideal with the same additivity as the ideal of meager sets. 2. There exists a strong measure zero set of size > d (dominating number).
arxiv  

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

open access: yesMolecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad   +13 more
wiley   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

Strong consistency rate in functional single index expectile model for spatial data

open access: yesAIMS Mathematics
Analyzing the real impact of spatial dependency in financial time series data is crucial to financial risk management. It has been a challenging issue in the last decade.
Zouaoui Chikr Elmezouar   +5 more
doaj   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

open access: yesMolecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou   +11 more
wiley   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

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