Results 61 to 70 of about 3,628,150 (288)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Large Eddy Simulation of Swirl Topology Evolution in Strong Oxidant Jet Milling Force Field [PDF]
Journal of Applied Fluid MechanicsIn this paper, Large Eddy Simulation (LES) is employed to investigate the evolution characteristics of a spiral jet mill. This study aims to provide a theoretical reference for the numerical simulation and design optimization of spiral jet mills.
Y. Yu, K. Chen, D. Wang, Y. Qin, J. Liu
doaj +1 more source
Improving the optomechanical entanglement and cooling by photothermal force
, 2012 Cooling and Entanglement in optomechanical systems coupled through radiation pressure and photothermal force is studied. To develop the photothermal model, we derive an expression for deformation constant of the force.
Abdi, Mehdi, Bahrampour, Ali Reza
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
, 2012 We investigate the Casimir effect between two-dimensional electron systems driven to the quantum Hall regime by a strong perpendicular magnetic field. In the large separation (d) limit where retardation effects are essential we find i) that the Casimir ...
A. H. MacDonald +4 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
工程科学学报, 2018 In geotechnical and mining engineering, numerous particle matters are involved in scientific and technical problems. Recognition and quantification of the structure and distribution of force chain networks using photoelastic experiments, for instance ...
LI Fei, YANG Liu, WANG Jin-an, WANG Chao
doaj +1 more source
Structural basis of αE-catenin–F-actin catch bond behavior
eLife, 2020 Cell-cell and cell-matrix junctions transmit mechanical forces during tissue morphogenesis and homeostasis. α-Catenin links cell-cell adhesion complexes to the actin cytoskeleton, and mechanical load strengthens its binding to F-actin in a direction ...
Xiao-Ping Xu +6 more
doaj +1 more source
Dynamic Response of Adhesion Complexes: Beyond the Single-Path Picture
, 2001 We analyze the response of molecular adhesion complexes to increasing pulling forces (dynamic force spectroscopy) when dissociation can occur along either one of two alternative trajectories in the underlying multidimensional energy landscape.
Ajdari, Armand +2 more
core +3 more sources