Results 71 to 80 of about 3,628,150 (288)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Arching of force chains in excavated granular material

Frontiers in Earth Science
The physical arch and the arch effect are related to many geotechnical problems, such as the stability of mine openings, a tunnel’s shape, and disaster prevention.
Meimei Wang, Meimei Wang, Jin-An Wang, Fei Li, Chao Liang, Chao Liang, Liu Yang   +6 more
doaj   +1 more source

Structural anisotropy and orientation-induced Casimir repulsion in fluids

, 2010
In this work we theoretically consider the Casimir force between two periodic arrays of nanowires (both in vacuum, and on a substrate separated by a fluid) at separations comparable to the period.
Dalvit, D. A. R., Joannopoulos, John D., Johnson, Steven G., McCauley, Alexander P., Rodriguez, Alejandro W., Rosa, F. S. S.   +5 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Two particle model for studying the effects of space-charge force on strong head-tail instabilities

Physical Review Accelerators and Beams, 2016
In this paper, we present a new two particle model for studying the strong head-tail instabilities in the presence of the space-charge force. It is a simple expansion of the well-known two particle model for strong head-tail instability and is still ...
Yong Ho Chin, Alexander Wu Chao, Michael M. Blaskiewicz   +2 more
doaj   +1 more source

Study on Deflection of Surrounding Rock Force Chain and Disaster Mechanism of Instability in Deep Stope

Shock and Vibration, 2020
The mechanism of force chain deflection and instability-caused disaster in the deep surrounding rock of large-scale stopes was examined in this study using theoretical analyses, laboratory experiments, PFC3D numerical simulations, and other comprehensive
Guang-Xiang Xie, Anying Yuan, Lei Wang
doaj   +1 more source

Effective forces between colloids at interfaces induced by capillary wave-like fluctuations

, 2006
We calculate the effective force mediated by thermally excited capillary waves between spherical or disklike colloids trapped at a fluid interface. This Casimir type interaction is shown to depend sensitively on the boundary conditions imposed at the ...
H Lehle, Krech M., Lehle H., M Oettel, Oettel M., S Dietrich   +5 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Strong Structural Controllability and Zero Forcing [PDF]

, 2019
In this chapter, we study controllability and output controllability of systems defined over graphs. Specifically, we consider a family of state-space systems, where the state matrix of each system has a zero/non-zero structure that is determined by a given directed graph.
van Waarde, Henk J., Monshizadeh, Nima, Trentelman, Harry L., Camlibel, M. Kanat   +3 more
openaire   +2 more sources