Results 81 to 90 of about 3,628,150 (288)
A constrained random-force model for weakly bending semiflexible polymers
, 2011 The random-force (Larkin) model of a directed elastic string subject to quenched random forces in the transverse directions has been a paradigm in the statistical physics of disordered systems. In this brief note, we investigate a modified version of the
A. I. Larkin +5 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
European Physical Journal C: Particles and Fields, 2017 The strongest constraints on the Yukawa-type corrections to Newton’s gravitational law and on the coupling constants of axion-like particles to nucleons, following from recently performed experiments of Casimir physics, are presented.
G. L. Klimchitskaya
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Decay rate of strong solutions to compressible Navier-Stokes-Poisson equations with external force
Electronic Journal of Differential Equations, 2019 In this article, we consider the three dimensional compressible Navier-Stokes-Poisson equations with the effect of external potential force. First, the stationary solution is established by solving a nonlinear elliptic system.
Yeping Li, Nengqiu hang
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Balanced Walking Force Control for Walking Excavators Based on Dual Strong Tracking Kalman Filter
Applied SciencesThe operation of walking excavators on rugged terrain often leads to leg lift-off, which can result in uneven force distribution, accelerated structural wear, and even systemic instability.
Zhen Liu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source