Results 81 to 90 of about 473,067 (264)

New Concepts of Vertex Covering in Cubic Graphs with Its Applications

Mathematics, 2022
Graphs serve as one of the main tools for the mathematical modeling of various human problems. Fuzzy graphs have the ability to solve uncertain and ambiguous problems.
Huiqin Jiang, Ali Asghar Talebi, Zehui Shao, Seyed Hossein Sadati, Hossein Rashmanlou   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

On Certain Products of Complex Intuitionistic Fuzzy Graphs

Journal of Function Spaces, 2021
A complex intuitionistic fuzzy set (CIFS) can be used to model problems that have both intuitionistic uncertainty and periodicity. A diagram composed of nodes connected by lines and labeled with specific information may be used to depict a wide range of ...
Abida Anwar, Faryal Chaudhry
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Resolvability and Strong Resolvability in the Direct Product of Graphs [PDF]

Results in Mathematics, 2016
Given a connected graph $G$, a vertex $w\in V(G)$ distinguishes two different vertices $u,v$ of $G$ if the distances between $w$ and $u$ and between $w$ and $v$ are different. Moreover, $w$ strongly resolves the pair $u,v$ if there exists some shortest $u-w$ path containing $v$ or some shortest $v-w$ path containing $u$.
Dorota Kuziak, Iztok Peterin, Ismael G. Yero   +2 more
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Italian Domination Number for Strong Product of Cycles and Paths

Journal of Mathematics
This paper mainly considers the Italian domination number for strong product of cycles and paths. After constructing some recursive Italian dominating functions, we derive the upper bounds for the Italian domination number of strong product of cycles and
Liyang Wei, Feng Li
doaj   +1 more source

Resistance Distance in Tensor and Strong Product of Path or Cycle Graphs Based on the Generalized Inverse Approach

Journal of Mathematics, 2021
Graph product plays a key role in many applications of graph theory because many large graphs can be constructed from small graphs by using graph products. Here, we discuss two of the most frequent graph-theoretical products. Let G1 and G2 be two graphs.
Muhammad Shoaib Sardar, Xiang-Feng Pan, Dalal Alrowaili, Imran Siddique   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source